• Publications
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An inactivated enterovirus 71 vaccine in healthy children.
BACKGROUND Enterovirus 71 (EV71) is a major cause of hand, foot, and mouth disease in children and may be fatal. A vaccine against EV71 is needed. METHODS We conducted a randomized, double-blind,Expand
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Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China.
  • F. Zhu, W. Xu, +28 authors N. Wang
  • Medicine
  • The New England journal of medicine
  • 26 February 2014
BACKGROUND Enterovirus 71 (EV71) is one of the major causative agents of outbreaks of hand, foot, and mouth disease or herpangina worldwide. This phase 3 trial was designed to evaluate the efficacy,Expand
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Coxsackievirus A16
Coxsackievirus 16 (CA16) is one of the major pathogens associated with hand, foot, and mouth disease (HFMD) in infants and young children. In recent years, CA16 and human enterovirus 71 (EV71) haveExpand
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EV71 vaccine, a new tool to control outbreaks of hand, foot and mouth disease (HFMD)
ABSTRACT On December 3rd 2015, the China Food and Drug Administration (CFDA) approved the first inactivated Enterovirus 71 (EV71) whole virus vaccine for preventing severe hand, foot and mouthExpand
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Molecular Determinants of Enterovirus 71 Viral Entry
  • Pan Chen, Z. Song, +13 authors W. Li
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 4 January 2012
Background: SCARB2 is the cellular receptor for EV71. Results: Seven highly variable amino acids on SCARB2 and a region in proximity to residue Gln-172 of VP1 are critical for EV71 infection.Expand
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Coxsackievirus A6: a new emerging pathogen causing hand, foot and mouth disease outbreaks worldwide
Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the predominant pathogens causing outbreaks of hand, foot and mouth disease (HFMD) worldwide. Other human enterovirus A (HEV-A) serotypes tendExpand
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A Neonatal Mouse Model of Coxsackievirus A16 for Vaccine Evaluation
  • Q. Mao, Yiping Wang, +7 authors Jiahuai Wang
  • Medicine, Biology
  • Journal of Virology
  • 5 September 2012
ABSTRACT To evaluate vaccine efficacy in protecting against coxsackievirus A16 (CA16), which causes human hand, foot, and mouth disease (HFMD), we established the first neonatal mouse model. In thisExpand
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Retrospective Study of the Incidence of HFMD and Seroepidemiology of Antibodies against EV71 and CoxA16 in Prenatal Women and Their Infants
Background Hand, foot, and mouth disease (HFMD) has been emerging as an important public problem over the past few decades, especially in Asian and Pacific regions. A national program on EV71 vaccineExpand
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EV-A71 vaccine licensure: a first step for multivalent enterovirus vaccine to control HFMD and other severe diseases
Enteroviruses (EVs) are the most common viral agents in humans. Although most infections are mild or asymptomatic, there is a wide spectrum of clinical manifestations that may be caused by EVExpand
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Enterovirus 71 viral capsid protein linear epitopes: Identification and characterization
  • Fan Gao, Yiping Wang, +8 authors J. Wang
  • Medicine, Biology
  • Virology Journal
  • 20 January 2012
BackgroundTo characterize the human humoral immune response against enterovirus 71 (EV71) infection and map human epitopes on the viral capsid proteins.MethodsA series of 256 peptides spanning theExpand
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