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Participatory Game Design for the INTERACCT Serious Game for Health
TLDR
Results from the user-centered and participative design approach using methods from design thinking and explorative design with school children aged 8 - 14 in context with a game created for children after cancer treatment act as important guidelines for designing the game world.
Lipophilicity as a determinant of thiazolidinedione action in vitro: findings from BLX-1002, a novel compound without affinity to PPARs.
TLDR
It is suggested that impairment of mitochondrial function and increased anaerobic fuel metabolism are unlikely to account for PPARγ-independent glucose lowering by BLX-1002, and that higher lipophilicity of an individual TZD is associated with stronger acceleration of an aerobic glycolysis.
Usability and Fun of the INTERACCT Client
TLDR
The INTERACCT system, a smartphone app and a Web page for fostering communication between young patients in aftercare after a stem cell transplantation and an evaluation of the app with several healthy children are described.
A Participatory Game Design Approach for Children After Cancer Treatment
TLDR
The design of INTERACCT is key to its success, and results from the user-centric and participative design approach using methods from design thinking and explorative design with school children aged 8-14 are presented, which will inspire the game design of theINTERACCT computer games.
Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes?
TLDR
The antihyperglycaemic potency of (±)-efaroxan in mice is almost entirely due to α2-antagonism, but high doses can also lower blood glucose via another mechanism, which implicates a different mechanism of action.
55P0110, a Novel Synthetic Compound Developed from a Plant Derived Backbone Structure, Shows Promising Anti-Hyperglycaemic Activity in Mice
TLDR
A novel class of fully synthetic substituted quinazolidines with an attractive pharmacological profile is discovered that recommends the structures for further evaluation as candidates for the treatment of diabetes mellitus.
Serious Game Scores as Health Condition Indicator for Cancer Patients
TLDR
The challenges of designing such a system are outlined and a solution for the medical data interface and evaluation is presented.
Dissection of mechanisms that account for imidazoline-induced lowering of blood glucose in mice.
TLDR
The results show that imidazolines can lower blood glucose via more than one mechanism of action, with the relative contributions of the mechanisms varying considerably between individual compounds.
Preclinical characterization of 55P0251, a novel compound that amplifies glucose‐stimulated insulin secretion and counteracts hyperglycaemia in rodents
55P0251 is a novel compound with blood glucose lowering activity in mice, which has been developed from a molecular backbone structure found in herbal remedies. We here report its basic
Evidence that the multiflorine‐derived substituted quinazolidine 55P0251 augments insulin secretion and lowers blood glucose via antagonism at α2‐adrenoceptors in mice
To investigate the mechanism of action of 55P0251, a novel multiflorine‐derived substituted quinazolidine that augments insulin release and lowers blood glucose in rodents, but does not act via