Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review
Laron syndrome (primary growth hormone resistance or insensitivity): the personal experience 1958-2003.
- Z. Laron
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 March 2004
This review presents the personal experience gained from the study follow-up and treatment of the 60 patients followed up for many years in the Israeli cohort and shows the GH-independent IGF-I effects.
Insulin-like growth factor 1 (IGF-1): a growth hormone
- Z. Laron
- Medicine, BiologyMolecular Pathology
- 1 October 2001
IGF-1 is an important growth hormone, mediating the protein anabolic and linear growth promoting effect of pituitary GH and has a GH independent growth stimulating effect, which with respect to cartilage cells is possibly optimised by the synergistic action with GH.
Mathematical formulae for the prediction of the residual beta cell function during the first two years of disease in children and adolescents with insulin-dependent diabetes mellitus.
Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism.
Characterization of the growth hormone receptor gene from nine patients with Laron-type dwarfism shows that two individuals have a deletion of a large portion of the extracellular, hormone binding domain of the receptor gene.
Comparative skeletal features between Homo floresiensis and patients with primary growth hormone insensitivity (Laron Syndrome).
- I. Hershkovitz, L. Kornreich, Z. Laron
- Medicine, BiologyAmerican Journal of Physical Anthropology
- 1 October 2007
The findings from the island of Flores, which were attributed to a new species of the genus Homo, may in fact represent a local, highly inbred, Homo sapiens population in whom a mutation for the GH receptor had occurred.
Insulin analogues display IGF‐I‐like mitogenic and anti‐apoptotic activities in cultured cancer cells
- D. Weinstein, M. Simon, E. Yehezkel, Z. Laron, H. Werner
- Biology, MedicineDiabetes/Metabolism Research Reviews
- 1 January 2009
The aim of this study was to investigate whether two long‐acting insulin analogues and two short‐acting analogues exhibit IGF‐I‐like activities on cultured cancer cells in comparison with IGF-I and regular human insulin.
Geographic Differences in the Risk of Insulin-dependent Diabetes Mellitus: The Importance of Registries
The major needs for the future studies include to clarify the definition of IDDM for epidemiologic study, to establish a standardized approach for IDDM registries, to use registries to evaluate viral, immunologic, and genetic differences in order to explain differential risks across populations, and to encourage the development of new population-based registries worldwide.
Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee.
Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies.
The findings bear heavily on the relationship between GH/IGF1 and cancer.