• Publications
  • Influence
Type I corticosteroid receptor‐like immunoreactivity in the rat CNS: Distribution and regulation by corticosteroids
TLDR
This work has used two antisera against peptide sequences derived from the cDNA of the human Type I corticosteroid receptor to map the regional distribution and cortiosteroid regulation of the intracellular location of Type I Corticosteroids receptor‐like immunoreactivity (Type I‐ir) in the rat CNS. Expand
Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme
TLDR
The isolation of a cDNA coding for human 11 beta HSD2 suggests that 11 betaHSD2 plays an important role in modulating mineralocorticoid and glucoc Corticoid receptor occupancy by glucOCorticoids. Expand
Sympathetic Augmentation in Hypertension: Role of Nerve Firing, Norepinephrine Reuptake, and Angiotensin Neuromodulation
TLDR
Increased rates of sympathetic nerve firing and reduced neuronal NE reuptake both contribute to sympathetic activation in hypertension, whereas a role for dampened arterial baroreflex restraint on sympathetic nerve traffic and a peripheral neuromodulating influence of angiotensin II appear to be excluded. Expand
Partial colocalization of glucocorticoid and mineralocorticoid receptors in discrete compartments in nuclei of rat hippocampus neurons.
TLDR
The spatial distribution of these transcription factors in nuclei of CA1 neurons is studied by dual labeling immunocytochemistry and confocal microscopy, combined with novel image restoration and image analysis techniques, finding that both receptors are concentrated in about one thousand clusters within the nucleus. Expand
Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity.
TLDR
It is suggested that hippocampal [3H]corticosterone-binding sites and renal MR may have identical intrinsic specificity for steroids, with apparent specificity differences the result of tissue-specific sequestration of naturally occurring steroids other than Aldo. Expand
Immunohistochemical localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme in human kidney and placenta.
TLDR
The results suggest that the 11 beta HSD2 enzyme colocalizes with the mineralocorticoid receptor in the distal nephron where it allows aldosterone to occupy its physiological receptor. Expand
Hexose-6-phosphate dehydrogenase and 11beta-hydroxysteroid dehydrogenase-1 tissue distribution in the rat.
TLDR
H6PDH was found in a wide variety of tissues, with the greatest concentrations in the liver, kidney, and Leydig cells, and some neurons were clearly immunoreactive by immunohistochemistry. Expand
Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess.
TLDR
Early and vigilant treatment of AME patients may prevent or improve the morbidity and mortality of end-organ damage such as renal or cardiovascular damage and retinopathy and the outcome of treatment in more patients may establish the efficacy of treatment. Expand
Type I and type II corticosteroid receptor gene expression in the rat: effect of adrenalectomy and dexamethasone administration.
TLDR
Using 32P-labeled cRNA probes directed against Type I and Type II receptor mRNA to screen various tissues, and investigating the effect of adrenalectomy and dexamethasone administration on their levels in hippocampus found Type I mRNA to be high in hippocampus, colon, and heart; low in liver; and undetectable in thymus. Expand
High-affinity anti-oestrogen binding site distinct from the oestrogen receptor
TLDR
A further high-affinity, anti-oestrogen binding site is reported which may have a role in regulating the effects of non-steroidal anti-Oestrogens. Expand
...
1
2
3
4
5
...