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A search for BACE inhibitors reveals new biosynthetically related pyrrolidones, furanones and pyrroles from a southern Australian marine sponge, Ianthella sp.
- Hua Zhang, M. Conte, Xiao-cong Huang, Z. Khalil, R. Capon
- ChemistryOrganic & biomolecular chemistry
- 7 April 2012
The ianthellidones were non-cytotoxic towards two human colon cancer cell lines, as well as Gram +ve and Gram -ve bacteria, and a fungus, and Structures for all Ianthella metabolites were determined by detailed spectroscopic analysis, supported by a plausible biosynthetic relationship.
Cytochalasins from an Australian Marine Sediment-Derived Phomopsis sp. (CMB-M0042F): Acid-Mediated Intramolecular Cycloadditions Enhance Chemical Diversity.
- Zhuo Shang, Ritesh Raju, A. Salim, Z. Khalil, R. Capon
- ChemistryThe Journal of organic chemistry
- 31 August 2017
Novel stereo- and regiospecific intramolecular cycloadditions are proposed, under tight functional group control, that facilitate selective conversion of 1 and 2 to the rare 5/6/6-7/5- and 5/ 6/5/8-fused heterocycles 5 and 7, respectively.
Levofloxacin and indolicidin for combination antimicrobial therapy.
- K. Ghaffar, W. M. Hussein, Z. Khalil, R. Capon, M. Skwarczynski, I. Toth
- Biology, ChemistryCurrent drug delivery
- 31 January 2015
Conjugated the antibiotic, levofloxacin, with two peptides, i.e. an antimicrobial peptide indolicidin and a cell penetrating peptide (TAT) and showed improvement in the activity against Gram-positive bacteria.
New dictyodendrins as BACE inhibitors from a southern Australian marine sponge, Ianthella sp.
Dictyodendrin J (5), with its unique seco-carbon skeleton and unusual 1,2-diketone functionality, exhibited a promising non-cytotoxic biological activity profile, inclusive of significant BACE inhibitory activity (IC50 2 μM), supportive of further investigation.
Heterofibrins: inhibitors of lipid droplet formation from a deep-water southern Australian marine sponge, Spongia (Heterofibria) sp.
A bioassay-guided search for inhibitors of lipid droplet formation in a deep-water southern Australian marine sponge yielded six new compounds, fatty acids heterofibrins A1 and B1, along with related monolactyl and dilactyl esters, which were confirmed to be non-cytotoxic.
Isolation and synthesis of N-acyladenine and adenosine alkaloids from a southern Australian marine sponge, Phoriospongia sp.
Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus.
Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus.
A search for kinase inhibitors and antibacterial agents: bromopyrrolo-2-aminoimidazoles from a deep-water Great Australian Bight sponge, Axinella sp.
Heronapyrroles A-C: farnesylated 2-nitropyrroles from an Australian marine-derived Streptomyces sp.
- Ritesh Raju, Andrew M. Piggott, Leticia Barrientos Díaz, Z. Khalil, R. Capon
- Chemistry, BiologyOrganic letters
- 15 October 2010
Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0423) isolated from beach sand off Heron Island, Australia, yielded three new members of the rare pyrroloterpene biosynthetic structure…