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Closed-Loop Deep Brain Stimulation Is Superior in Ameliorating Parkinsonism
Continuous high-frequency deep brain stimulation (DBS) is a widely used therapy for advanced Parkinson's disease (PD) management. However, the mechanisms underlying DBS effects remain enigmatic andExpand
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Subthalamic span of beta oscillations predicts deep brain stimulation efficacy for patients with Parkinson's disease.
The significance of oscillations that characterize the subthalamic nucleus in Parkinson's disease is still under debate. Here, we analysed the spectral and spatial characteristics of 314Expand
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Inducing Gamma Oscillations and Precise Spike Synchrony by Operant Conditioning via Brain-Machine Interface
Neural oscillations in the low-gamma range (30-50 Hz) have been implicated in neuronal synchrony, computation, behavior, and cognition. Abnormal low-gamma activity, hypothesized to reflect impairedExpand
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Subthalamic stimulation for Parkinson's disease.
Subthalamic nucleus stimulation by means of permanently implanted brain electrodes is a very effective therapy for all the cardinal features of Parkinson's disease. In appropriate patients, motorExpand
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Delimiting subterritories of the human subthalamic nucleus by means of microelectrode recordings and a Hidden Markov Model
Positive therapeutic response without adverse side effects to subthalamic nucleus deep brain stimulation (STN DBS) for Parkinson's disease (PD) depends to a large extent on electrode location withinExpand
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Akineto-rigid vs. tremor syndromes in Parkinsonism
Purpose of reviewAkinesia, rigidity and low-frequency rest tremor are the three cardinal motor signs of Parkinson's disease and some Parkinson's disease animal models. However, cumulative evidenceExpand
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Temporal Convergence of Dynamic Cell Assemblies in the Striato-Pallidal Network
The basal ganglia (BG) have been hypothesized to implement a reinforcement learning algorithm. However, it is not clear how information is processed along this network, thus enabling it to performExpand
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Radiation‐Induced Meningioma: A Distinct Molecular Genetic Pattern?
Radiation-induced meningiomas arise after low-dose irradiation treatment of certain medical conditions and are recognized as clinically separate from sporadic meningioma. These tumors are oftenExpand
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Real‐time refinement of subthalamic nucleus targeting using Bayesian decision‐making on the root mean square measure
The subthalamic nucleus (STN) is a major target for treatment of advanced Parkinson's disease patients undergoing deep brain stimulation surgery. Microelectrode recording (MER) is used in many casesExpand
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Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia
Histone lysine methylation, mediated by mixed-lineage leukemia (MLL) proteins, is now known to be critical in the regulation of gene expression, genomic stability, cell cycle and nuclearExpand
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