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Ablation of Undifferentiated Human Embryonic Stem Cells: Exploiting Innate Immunity Against the Gal α1‐3Galβ1‐4GlcNAc‐R (α‐Gal) Epitope
Although undifferentiated human embryonic stem cells (hESCs) are tumorigenic, this capacity is lost after differentiation, and hESCs are being widely investigated for applications in regenerativeExpand
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Fluorescence-activated single cell sorting of human embryonic stem cells.
Human embryonic stem cells (hESC) are the subject of intense investigation for use in regenerative medicine, in toxicity testing, and as models for the study of human development. Automated cellExpand
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Ablation of undifferentiated human embryonic stem cells: exploiting innate immunity against the Gal alpha1-3Galbeta1-4GlcNAc-R (alpha-Gal) epitope.
Although undifferentiated human embryonic stem cells (hESCs) are tumorigenic, this capacity is lost after differentiation, and hESCs are being widely investigated for applications in regenerativeExpand
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Derivation of GMP Raw Materials for Use in Regenerative Medicine: hESC‐based Therapies, Progress Toward Clinical Application
The potential of somatic cell therapies from human embryonic stem cells (hESCs) as alternatives to traditional drug‐based remedies for treating some of mankind's most debilitating diseases hasExpand
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Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions
The occurrence of repetitive genomic changes that provide a selective growth advantage in pluripotent stem cells is of concern for their clinical application. However, the effect of different cultureExpand
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Nucleosides Rescue Replication-Mediated Genome Instability of Human Pluripotent Stem Cells
Summary Human pluripotent stem cells (PSCs) are subject to the appearance of recurrent genetic variants on prolonged culture. We have now found that, compared with isogenic differentiated cells, PSCsExpand
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Stem cell culture conditions and stability: a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform.
Human stem cells have the potential to transform medicine. However, hurdles remain to ensure that manufacturing processes produce safe and effective products. A thorough understanding of theExpand
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Autophagic response to cell culture stress in pluripotent stem cells.
Autophagy is an important conserved cellular process, both constitutively as a recycling pathway for long lived proteins and as an upregulated stress response. Recent findings suggest a fundamentalExpand
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Nucleosides rescue replication-mediated genome instability of human pluripotent stem cells
Human pluripotent stem cells (PSC) often acquire genetic changes on prolonged culture, which pose concerns for their use in research and regenerative medicine (Amps et al., 2011, Seth et al., 2011).Expand
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GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells
A major challenge for the clinical use of human pluripotent stem cells is the development of safe, robust and controlled differentiation protocols. Adaptation of research protocols using reagentsExpand
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