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TNFα-dependent development of lymphoid tissue in the absence of RORγt+ Lymphoid Tissue Inducer cells
Lymphoid tissue often forms within sites of chronic inflammation. Here we report that expression of the proinflammatory cytokine tumor necrosis factor α (TNFα) drives development of lymphoid tissueExpand
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Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice
The development of serrated polyps in the cecum is driven by the interplay among genetic changes in the host, an inflammatory response, and a host-specific microbiota.
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Epithelial-derived IL-33 promotes intestinal tumorigenesis in ApcMin/+ mice
Increased expression of Interleukin (IL)-33 has been detected in intestinal samples of patients with ulcerative colitis, a condition associated with increased risk for colon cancer, but its role inExpand
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IL-23 activates innate lymphoid cells to promote neonatal intestinal pathology
Interleukin-23 (IL-23) responsive group 3 innate lymphoid cells (ILC3s) have been implicated in immune homeostasis and pathogenesis in the adult, but little is known about their roles in the newborn.Expand
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Host and microbiota interactions are critical for development of murine Crohn's-like ileitis
Deregulation of host-microbiota interactions in the gut is a pivotal characteristic of Crohn’s disease. It remains unclear, however, whether commensals and/or the dysbiotic microbiota associated withExpand
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Diet Modifies Colonic Microbiota and CD4+ T-Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-Cell Expression of Interleukin 23.
BACKGROUND & AIMS Several studies have shown that signaling via the interleukin 23 (IL23) receptor is required for development of colitis. We studied the roles of IL23, dietary factors, alterationsExpand
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Interleukin 33 regulates gene expression in intestinal epithelial cells independently of its nuclear localization
HighlightsExpression of full‐length IL33 in IEC resulted in accumulation of protein in the nucleus and secretion.IL33 induced differential gene expression in IEC and LPL that was negativelyExpand
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Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity.
Group 2 innate lymphoid cells (ILC2s) regulate immunity, inflammation, and tissue homeostasis. Two distinct subsets of ILC2s have been described: steady-state natural ILC2s and inflammatory ILC2s,Expand
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Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23
Neonatal inflammatory diseases are associated with severe morbidity, but the inflammatory factors underlying them and their potential effector mechanisms are poorly defined. Here we show thatExpand
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Interleukin 1 beta and Matrix Metallopeptidase 3 Contribute to Development of EGFR-dependent Serrated Polyps in Mouse Cecum.
BACKGROUND & AIMS Transgenic mice (HBUS) that express the epidermal growth factor (EGFR) ligand HBEGF and a constitutively active G protein-coupled receptor (US28) in intestinal epithelial cellsExpand
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