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Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials.
BACKGROUND AND OBJECTIVES Adult bone marrow (BM) is the major source of mesenchymal stem cells (MSC) for cell therapy. However, aspiration of BM involves invasive procedures. We isolated MSC from… Expand
c-Myc Is Necessary for DNA Damage-Induced Apoptosis in the G2 Phase of the Cell Cycle
- Shinya Adachi, A. Obaya, Z. Han, N. Ramos-Desimone, J. Wyche, J. Sedivy
- Biology, Medicine
- Molecular and Cellular Biology
- 1 August 2001
ABSTRACT The c-myc proto-oncogene encodes a transcription factor that participates in the regulation of cellular proliferation, differentiation, and apoptosis. Ectopic overexpression of c-Myc has… Expand
Angiogenesis: state of the art.
Considerable progress has been made recently in understanding the molecular mechanisms of angiogenesis, the formation of new blood vessels by a process of sprouting from preexisting vessels.… Expand
Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF).
Stem cell factor (SCF) plays important roles in tumor growth and angiogenesis. However, its regulatory mechanism remains largely undefined. Here, we report that hypoxia upregulated the expression of… Expand
Human umbilical cord blood cells express neurotrophic factors
- Cun-Gang Fan, Qing-jun Zhang, F. Tang, Z. Han, Z. Han
- Biology, Medicine
- Neuroscience Letters
- 3 June 2005
Freshly isolated or culture-expanded human umbilical cord blood mononuclear cells (CBMNCs) have been known to express neural phenotypes in vitro and to differentiate into neural cells and improve… Expand
[Expression of inducible nitric oxide synthase in human esophageal biopsies from carcinoma and precancerous lesions].
- Y. Jin, W. Zhang, +9 authors P. Lin
- Zhongguo yi xue ke xue yuan xue bao. Acta…
- 1 December 2000
OBJECTIVE To investigate the possible role of inducible nitric oxide synthase (iNOS) in esophageal carcinogenesis. METHODS iNOS expressions in normal epithelial cells(NC), hyperplastic cells(HC),… Expand
[Expression of vascular endothelial growth factor and its receptors KDR and Flt1 in acute myeloid leukemia].
- Y. Wang, Z. Xiao, +4 authors Z. Han
- Zhonghua xue ye xue za zhi = Zhonghua xueyexue…
- 1 May 2003
OBJECTIVE To evaluate the expression of vascular endothelial growth factor (VEGF) and its receptors KDR and Flt1 in patients with acute myeloid leukemia (AML). METHODS The expression of VEGF and… Expand
Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway
- Bao-quan Song, Y. Chi, +10 authors Z. Han
- Chemistry, Medicine
- Cellular Physiology and Biochemistry
Background: The Notch signaling pathway is implicated in a broad range of developmental processes, including cell fate decisions. This study was designed to determine the role of Notch signaling in… Expand
Prostaglandin E2 hydrogel improves cutaneous wound healing via M2 macrophages polarization
Wound healing is regulated by a complex series of events and overlapping phases. A delicate balance of cytokines and mediators in tissue repair is required for optimal therapy in clinical… Expand
Lovastatin restores the function of endothelial progenitor cells damaged by oxLDL
AbstractAim:The aim of the study was to investigate whether lovastatin restores the survival and function of endothelial progenitor cells (EPCs) damaged by oxLDL.Methods:EPCs were preincubated with… Expand