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Lipidomics reveals a remarkable diversity of lipids in human plasma1[S]
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids and to quantitatively assessed the levels of over 500 distinct molecular species distributed among the main lipid categories.
Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates
- Brandon K Tan, M. Bogdanov, Jinshi Zhao, W. Dowhan, C. Raetz, Z. Guan
- Biology, ChemistryProceedings of the National Academy of Sciences
- 17 September 2012
The combined YmdB-ClsC gene pair used PE as the phosphatidyl donor to PG to form CL, which demonstrates a third and unique mode for CL synthesis.
Biomarkers of NAFLD progression: a lipidomics approach to an epidemic1[S]
An “omics” approach to detecting a reproducible signature of lipid metabolites, aqueous intracellular metabolites, SNPs, and mRNA transcripts in a double-blinded study of patients with different stages of NAFLD that involves profiling liver biopsies, plasma, and urine samples is described.
Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis
The crystal structure of MraY from Aquifex aeolicus (MraYAA) is presented, which allows us to visualize the overall architecture, locate Mg2+ within the active site, and provide a structural basis of catalysis for this class of enzyme.
Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis.
Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1.
- Ming Li, H. Phatnani, Z. Guan, H. Sage, A. Greenleaf, P. Zhou
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 6 December 2005
The solution structure of the SRI domain in human Set2 (hSRI domain), which adopts a left-turned three-helix bundle distinctly different from other structurally characterized PCTD-interacting domains, is reported.
SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder
Cardiolipin and the osmotic stress responses of bacteria.
Subcellular organelle lipidomics in TLR-4-activated macrophages1[S]
An analysis of the subcellular lipidome of the mammalian macrophage, a cell type that plays key roles in inflammation, immune responses, and phagocytosis, reports changes in lipid composition that may reflect mitochondrial oxidative stress and the release of arachidonic acid from the ER in response to cell activation.
Remodelling of the Vibrio cholerae membrane by incorporation of exogenous fatty acids from host and aquatic environments
The results suggest that Vibrio species possess unique machinery conferring the ability to take up a wider range of exogenous fatty acids than other enteric bacteria.