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The role of RPA2 phosphorylation in homologous recombination in response to replication arrest.
Failure to reactivate stalled or collapsed DNA replication forks is a potential source of genomic instability. Homologous recombination (HR) is a major mechanism for repairing the DNA damage… Expand
DNA repair and synthetic lethality
- Gongshe Guo, Feng-mei Zhang, Rui Gao, R. Delsite, Z. Feng, S. Powell
- Biology, Medicine
- International Journal of Oral Science
- 1 October 2011
Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair‐defective… Expand