Z. Fan

Publications25
h-index8
Citations176
Highly Influential Citations4
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Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion.
MicroRNA-320 was downregulated in non-small cell lung cancer and inhibited cell proliferation, migration and invasion by targeting fatty acid synthase.
TLDR
Evidence is provided that miR‑320 may serve as a therapeutic biomarker of NSCLC in the future and that it is possible to directly target fatty acid synthase through reverse transcription‑quantitative polymerase chain reaction.
Screening key lncRNAs for human lung adenocarcinoma based on machine learning and weighted gene co-expression network analysis.
TLDR
The optimal diagnostic lncRNA biomarkers for LUAD were identified by using feature selection procedure and classification model and functional annotation of pink and green modules provided new evidences for exploring the precise roles of lncRNAs in LUAD.
Melatonin Ameliorates Renal Fibrosis Though the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice.
Effect of zinc supplementation on type 2 diabetes parameters and liver metallothionein expressions in Wistar rats
TLDR
Both zinc and MT could play an important role in balancing nutrition and metabolism to prevent diabetic development, and zinc levels in liver were increased while there was no change in serum zinc levels, indicating that local zinc level might be a critical factor for the induction of MTs.
Modification of α2,6‐sialylation mediates the invasiveness and tumorigenicity of non‐small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway
TLDR
Modification of α2,6‐sialylation positively associates with lung cancer progression, thereby indicating that ST6Gal‐I may mediate the invasiveness and tumorigenicity of NSCLC cells via the Notch1/Hes1/MMPs pathway both in vitro and in vivo.
Endogenous microRNA-424 predicts clinical outcome and its inhibition acts as cancer suppressor in human non-small cell lung cancer.
LncRNA NBAT-1 is down-regulated in lung cancer and influences cell proliferation, apoptosis and cell cycle.
TLDR
The low expression of lncRNA NBAT-1 is involved in the progression of lung cancer and could inhibit the proliferation and cell cycle, promote the apoptosis of A549 cells, and down-regulate the expression level of RAC1.
Role of TGF-β activated kinase-1 inhibitor on the interaction between macrophages and mesangial cells on the condition of high glucose
TLDR
TAK1 inhibitor can reduce the secretion of inflammation cytokines and extracellular matrix components by intervening NF-κB p65 nuclear transfer and inhibiting macrophage migration.
Inhibitor of Bruton's tyrosine kinases, PCI‐32765, decreases pro‐inflammatory mediators' production in high glucose‐induced macrophages
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