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Endogenous morphine.
TLDR
This review surveys the discovery of endogenous alkaloids in mammals and shows that the biosynthetic pathway is similar to that that exists in poppy. Expand
The development of tolerance to locomotor effects of morphine and the effect of various opioid receptor antagonists in rats chronically treated with morphine
TLDR
Tolerance developed to the inhibitory action of morphine was observed even 8 weeks after morphine withdrawal, while tolerance to its locomotor activity enhancing effect was detected 18 h after withdrawal, but not 3 weeks later. Expand
Changes in adaptability following perinatal morphine exposure in juvenile and adult rats.
TLDR
It is shown that perinatal morphine exposure induces long term depression-like changes and the reactivity to the stress is failed, which presume that the progenies of morphine users could have lifelong problems in adaptive capability and might be prone to develop psychiatric disorders. Expand
Intermittent prenatal MDMA exposure alters physiological but not mood related parameters in adult rat offspring
TLDR
It is suggested that an intermittent prenatal MDMA exposure with an early first injection and a relatively low cumulative dose provokes mild but significant alterations in physical-physiological parameters and reduces motor skill learning in adulthood. Expand
New approach to the neurobiological mechanisms of addiction.
TLDR
The aim of this review is to collect and interpret the latest opinions in the development, the underlying mechanisms and therapy of addiction as a disease of central nervous system. Expand
3,4-Methylenedioxymethamphetamine (MDMA), but not morphine, alters APP processing in the rat brain.
TLDR
Results indicate that the chronic use of 'ecstasy', but not morphine, may be harmful via a novel mode of action, i.e. by altering the APP expression and processing in the brain. Expand
The influence of naloxone on barbiturate anesthesia and toxicity in the rat.
TLDR
The findings of this study indicate that therapeutic trials with relatively large doses of naloxone are justifiable in patients intoxicated with barbiturates. Expand
Highly potent novel opioid receptor agonist in the 14-alkoxymetopon series.
TLDR
It is concluded that the 14-alkoxymetopon derivatives studied are selective and potent agonists at mu opioid receptors, with reduced dependence liability. Expand
Side chain modifications change the binding and agonist properties of endomorphin 2.
TLDR
The data presented demonstrate that the C-terminal amide group has an essential role in the regulation of the binding and the agonist/antagonist properties of E2. Expand
Pain-inhibiting inhomogeneous static magnetic field fails to influence locomotor activity and anxiety behavior in mice: No interference between magnetic field- and morphine-treatment
TLDR
The long-lasting antinociceptive effect of SMF allows experiments under conditions, when in situ application of the SMF-producing device would be technically difficult or impossible; or where it would disturb the experiments. Expand
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