Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.
Melatonin's functions as an antioxidant include: a), direct free radical scavenging, b), stimulation of antioxidative enzymes, c), increasing the efficiency of mitochondrial oxidative phosphorylation and reducing electron leakage (thereby lowering free radical generation), and 3), augmenting the efficiencyof other antioxidants.
Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions.
- R. Reiter, D. Tan, M. Terrón, L. J. Flores, Z. Czarnocki
- BiologyActa Biochimica Polonica
- 9 March 2007
The review makes the point that melatonin's actions are uncommonly widespread in organs due to the fact that it works via membrane receptors, nuclear receptors/binding sites and receptor-independent mechanisms, i.e., the direct scavenging of free radicals.
Molecular cloning of melatonin 3‐hydroxylase and its production of cyclic 3‐hydroxymelatonin in rice (Oryza sativa)
- Kyungjin Lee, A. Zawadzka, Z. Czarnocki, R. Reiter, K. Back
- BiologyJournal of Pineal Research
- 1 November 2016
Prior to the identification of 3‐OHM in plants, cloning of M3H genes in plants has paved the way for the studies of melatonin in plants in terms of its multiple physiological roles.
Identification and synthesis of some contaminants present in 4-methoxyamphetamine (PMA) prepared by the Leuckart method.
- D. Błachut, K. Wojtasiewicz, Z. Czarnocki
- ChemistryForensic Science International
- 25 June 2002
Synthesis of Imperatorin Analogs and Their Evaluation as Acetylcholinesterase and Butyrylcholinesterase Inhibitors
- S. Granica, A. Kiss, Małgorzata Jarończyk, J. Maurin, A. Mazurek, Z. Czarnocki
- Chemistry, BiologyArchiv der Pharmazie
- 1 November 2013
The results of this study may be considered as the beginning of a search for potential anti‐Alzheimer's disease drugs based on the structure of natural furocoumarins.
Aromaticity: A Theoretical Concept of Immense Practical Importance
- T. M. Krygowski, M. Cyrański, Z. Czarnocki, G. Haefelinger, A. Katritzky
- Philosophy
- 24 March 2000
In vitro propagation of Withania somnifera and isolation of withanolides with immunosuppressive activity.
- M. Furmanowa, D. Gajdzis-Kuls, S. N. Upadhyay
- Biology, MedicinePlanta Medica
- 1 March 2001
The results indicate that Withania species may require longer time and better differentiation and also natural environment for the production of withaferin A.
Flow Photochemistry as a Tool for the Total Synthesis of (+)-Epigalcatin.
- K. Lisiecki, Z. Czarnocki
- ChemistryOrganic Letters
- 18 January 2018
The first total synthesis of (+)-epigalcatin was completed in a highly stereoselective manner starting from piperonal, 3,4-dimethylbenzaldehyde, and diethyl succinate to construct the cyclolignan framework by continuous-flow photocyclization of a chiral atropisomeric 1,2-bisbenzylidenesuccinate amide ester.
Fentanyl Family at the Mu-Opioid Receptor: Uniform Assessment of Binding and Computational Analysis
- Piotr F. J. Lipiński, P. Kosson, J. Sadlej
- Chemistry, BiologyMolecules
- 1 February 2019
Interestingly, it was possible to find nonlinear relationships between the binding affinity and the volume of the N-chain and/or anilide’s aromatic ring, which is consistent with the apolar character of interactions involved in ligand–receptor binding.
Simultaneous induction and blockade of autophagy by a single agent
- Karolina Kucharewicz, M. Dudkowska, E. Sikora
- Biology, ChemistryCell Death and Disease
- 1 March 2018
It is demonstrated that tacrine-melatonin heterodimer C10, a potent anti-Alzheimer’s disease drug, has an antiproliferative effect on MCF-7 breast cancer cells.
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