• Publications
  • Influence
Materials for Direct Compaction
  • 122
  • 5
Drug-Excipient Incompatibility Studies of the Dipeptide Angiotensin-Converting Enzyme Inhibitor, Moexipril Hydrochloride: Dry Powder vs Wet Granulation
The drug-excipient incompatibility screen for moexipril hydrochloride (1) using various isothermal stress methods is reported herein. It was found that most of the commonly used fillers,Expand
  • 48
  • 3
pH-solubility profiles or organic carboxylic acids and their salts.
  • Z. Chowhan
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1 September 1978
The solubilities of naproxen, 7-methylsulfinyl-2-xanthonecarboxylic acid, 7-methylthio-2-xanthonecarboxylic acid, and their sodium, potassium, calcium, and magnesium salts were determined as aExpand
  • 86
  • 2
Effect of the mode of super disintegrant incorporation on dissolution in wet granulated tablets.
The effect of the mode of super disintegrant incorporation in wet granulated tablets was investigated with three super disintegrants: sodium starch glycolate, crospovidone, and croscarmellose sodium.Expand
  • 51
  • 2
Everted rat intestinal sacs as an in vitro model for assessing absorptivity of new drugs.
An in vitro model that utilizes everted rat intestinal sacs was evaluated for assessing the absorptivity of several analogs of potential drug substances prior to formulation work and clinical trials.Expand
  • 24
  • 1
Effect of surfactants on percutaneous absorption of naproxen I: comparisons of rabbit, rat, and human excised skin.
The in vitro skin penetration model using excised skin from rats, rabbits, and humans was examined to evaluate the relative effect of surfactants on percutaneous absorption of naproxen. DifferencesExpand
  • 82
  • 1
Effect of formulation solubility and hygroscopicity on disintegrant efficiency in tablets prepared by wet granulation, in terms of dissolution.
The effect of tablet formulation solubility and hygroscopicity on the dissolution efficiency of three "super disintegrants" (sodium starch glycolate, crospovidone, and croscarmellose sodium) inExpand
  • 67
  • 1
Hardness increase induced by partial moisture loss in compressed tablets and its effect on in vitro dissolution.
The hardness increase induced by partial moisture loss in compressed tablets was studied. Several factors such as the type and percentage of the excipient, the water solubility and hygroscopicity ofExpand
  • 50
  • 1
The effect of aging on the dissolution of wet granulated tablets containing super disintegrants
Abstract The effect of aging at various storage conditions on the dissolution efficiency of tablets containing three ‘super disintegrants’ (croscarmellose sodium, crospovidone, and sodium starchExpand
  • 26
  • 1
Role of binders in moisture-induced hardness increase in compressed tablets and its effect on in vitro disintegration and dissolution.
  • Z. Chowhan
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1980
The role of commonly used binders in the moisture-induced hardness increase in compressed tablets containing lactose as a major excipient was studied. Tablets compressed from granulations containingExpand
  • 77
  • 1
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