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Calvacin: A New Antitumor Agent.
Comparative study of the thymidine kinase and thymidylate kinase activities and of the feedbach inhibition of thymidine kinase in normal and neoplastic human tissue.
SUMMARYActivitylevelsofthymidinekinaseandthymidylate kinaseweredetermined inextractsfrom23matchedhumanneoplasticandnormaltissuepairs.ThymidinekinaseactivitywashigherinthetumorthaninthecorrespondingExpand
A systematic investigation of the presence of growth-inhibitory substances in animal tissues.
Summary A systematic fractionation and screening of 28 different bovine or porcine tissues was carried out in order to investigate whether there are any “growth-regulatory factors” present in normalExpand
STRUCTURE‐ACTIVITY RELATIONSHIPS OF ALKYLATING AGENTS IN CANCER CHEMOTHERAPY *
There seems to be a widespread feeling among clinical investigators that the usefulness of alkylating agents in cancer chemotherapy has some inherent limitations and that the selectivity and range ofExpand
Differential responses of DNA and RNA polymerase to modifications of the template rat liver DNA caused by action of the carcinogen acetylaminofluorene in vivo and in vitro.
Abstract Rats were fed a diet containing 2-acetylaminofluorene fot periods of 2–32 weeks, then sacrificed; DNA isolated from their livers was used as template in RNA polymeraseExpand
Effects of 5-mercapto-2'-deoxyuridine on the incorporation of nucleosides into RNA and DNA in a primary lymphocyte culture system.
The effects of 5-mercapto-2'-deoxyuridine (MUdr) on DNA synthesis in a primary murine spleen lymphocyte culture system stimulated by phytohemagglutinin (PHA) were studied. Inhibition of thymidineExpand
QUANTITATIVE TWO-DIMENSIONAL THIN-LAYER CHROMATOGRAPHY OF DEOXYRIBONUCLEIC ACID COMPONENTS.
Abstract In studying the various parameters of normal and malignant mammalian tissues, it became apparent that there was a need for a rapid quantitative procedure for the determination ofExpand
Alterations of some macromolecular and biochemical properties of calf thymus DNA caused by "dual antagonists" and nitrogen mustard.
Summary Solutions of calf thymus DNA were incubated at 37°C with several compounds of a series of bis(1-aziridinyl)phosphinyl urethanes and with nitrogen mustard (HN2). Various concentrations, pH,Expand
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