Embryonic Lethality and Defective Neural Tube Closure in Mice Lacking Squalene Synthase*
- R. Tozawa, S. Ishibashi, N. Yamada
- BiologyJournal of Biological Chemistry
- 22 October 1999
It is speculated that cholesterol is required for the development, particularly of the nervous system, and that the chorioallantoic circulatory system is not mature enough to supply the rapidly growing embryos with maternal cholesterol at this developmental stage.
Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice.
- H. Yagyu, S. Ishibashi, N. Yamada
- BiologyJournal of Lipid Research
- 1 September 1999
Overproduction of LPL is protective against atherosclerosis even in the absence of apoE, and non-high density lipoproteins from LPL/APOEKO mice had lower triglyceride content, a smaller size, and a more positive charge compared with those from APOEKO.
Impaired learning and memory in rats induced by a high‐fat diet: Involvement with the imbalance of nesfatin‐1 abundance and copine 6 expression
- Z. Chen, Y.Y. Xu, Fang-Han Chen
- BiologyJournal of neuroendocrinology
- 1 April 2017
It is suggested that consuming of a high‐fat diet for 4 consecutive weeks could successfully induce a NAFLD rat model and the first evidence of an increased plasma nesfatin‐1 concentration inNAFLD rats is provided, which was significantly correlated with plasma lipid concentrations and behavioural performance.
Thiazolidinedione- and tumor necrosis factor alpha-induced downregulation of peroxisome proliferator-activated receptor gamma mRNA in differentiated 3T3-L1 adipocytes.
- S. Perrey, S. Ishibashi, N. Yamada
- BiologyMetabolism: Clinical and Experimental
- 2001
In fully differentiated 3T3-L1 adipocytes, TZDs markedly decreased PPARgamma mRNA levels without reducing the expression of genes that are positively regulated by PPARGamma, such as adipocyte lipid-binding protein 2 (aP2) or lipoprotein lipase-(LPL).
The LDL receptor is the major pathway for beta-VLDL uptake by mouse peritoneal macrophages.
- S. Perrey, S. Ishibashi, N. Yamada
- Biology, MedicineAtherosclerosis
- 2001
Effects of probucol on atherosclerosis of apoE-deficient or LDL receptor-deficient mice.
- T. Yoshikawa, H. Shimano, Z. Chen, S. Ishibashi, N. Yamada
- Biology, MedicineHormone and metabolic research = Hormon- und…
- 1 August 2001
The effect of probucol on atheroma formation was evaluated using mouse models for atherosclerosis with different diet protocols. Dietary administration of probucol (0.5 %, wt/wt) for 12 weeks reduced…