Z. Chen

Publications63
h-index30
Citations4,290
Highly Influential Citations190
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PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis
TLDR
It is demonstrated that PGC-1α is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life. Expand
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.
TLDR
It is demonstrated that the expression of lipin 1 is induced by peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha (PGC-1alpha), a transcriptional coactivators controlling several key hepatic metabolic pathways. Expand
Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway
TLDR
It is demonstrated that the expression of lipin 1 is induced by peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha (PGC-1alpha), a transcriptional coactivators controlling several key hepatic metabolic pathways. Expand
Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity.
TLDR
It is concluded that PGC-1 coactivators are necessary for the oxidative and mitochondrial programs of skeletal muscle but are dispensable for fundamental fiber type determination and insulin sensitivity. Expand
Lipin 2 Is a Liver-enriched Phosphatidate Phosphohydrolase Enzyme That Is Dynamically Regulated by Fasting and Obesity in Mice*
TLDR
RNAi against lipin 2 markedly reduced PAP-1 activity in hepatocytes from both wild type and fld mice and suppressed triglyceride synthesis under conditions of high fatty acid availability, suggesting thatlipin 2 plays an important role as a hepatic P AP-1 enzyme. Expand
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis.
TLDR
A key role is identified for the inositol-requiring transmembrane kinase/endoribonuclease 1α-X box binding protein 1 (XBP1) arm of the UPR in regulation of hepatic very low-density lipoprotein (VLDL) assembly and secretion and may provide a therapeutic target for disorders of lipid metabolism. Expand
Role of the Low Density Lipoprotein (LDL) Receptor Pathway in the Metabolism of Chylomicron Remnants
TLDR
The LDLR pathway plays a significant role in the chylomicron remnant metabolism in mice fed a normal chow, and agarose gel electrophoresis revealed that an oral fat load resulted in retention of chylomaticrons in the LDLR(−/−) mice, which was not seen in wild-type mice. Expand
Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis
TLDR
Trehalose-mediated inhibition of glucose transport induced AMPK (adenosine 5′-monophosphate–activated protein kinase)–dependent autophagy and regression of hepatic steatosis in vivo and a reduction in the accumulation of lipid droplets in primary murine hepatocyte cultures. Expand
Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling.
TLDR
An important role for MPC2 is demonstrated in controlling hepatic gluconeogenesis and a compensatory mechanism for circumventing a block in mitochondrial pyruvate import is illuminated. Expand
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals.
TLDR
Adipose tissue from MAO individuals contains increased numbers of Th17 and Th22 cells, which produce cytokines that cause metabolic dysfunction in liver and muscle in vitro, which contributes to the pathogenesis of insulin resistance in obese people. Expand
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