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Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance
Cerebral ischemia-reperfusion (I-R) is a complex pathological process. Although autophagy can be evoked by ischemia, its involvement in the reperfusion phase after ischemia and its contribution to… Expand
Microglial migration mediated by ATP-induced ATP release from lysosomes
Microglia are highly motile cells that act as the main form of active immune defense in the central nervous system. Attracted by factors released from damaged cells, microglia are recruited towards… Expand
Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats
AbstractAim:To investigate the role of histamine in memory deficits induced by MK-801 infusion into the ventral hippocampus in rats.Methods:An 8-arm radial maze (4 arms baited) was used to assess… Expand
Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury
Transient cerebral ischemia leads to endoplasmic reticulum (ER) stress. However, the contributions of ER stress to cerebral ischemia are not clear. To address this issue, the ER stress activators… Expand
Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons
Shen et al. demonstrate a developmental role of astrocytes in shaping a predisposition to seizure generation. Activation of TLR4–MyD88–ERK1/2 signaling pathway in astrocytes during a critical… Expand
Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathway respectively in PC12…
PC12-GFRalpha1 cells, a clonal cell line engineered to express glial cell line-derived neurotrophic factor receptor alpha1 were constructed. Given glial cell line-derived neurotrophic factor could… Expand
Therapeutic potential of an anti-high mobility group box-1 monoclonal antibody in epilepsy
Brain inflammation is a major factor in epilepsy, and the high mobility group box-1 (HMGB1) protein is known to contribute significantly to the generation of seizures. Here, we investigated the… Expand
Reversal of scopolamine-induced spatial memory deficits in rats by TAK-147.
AIM To evaluate effect of TAK-147 on spatial memory deficit induced by scopolamine. METHODS Morris water maze was used to measure spatial memory in rats and open field test was used to analyse… Expand
Facilitating effect of histamine on spatial memory deficits induced by dizocilpine as evaluated by 8-arm radial maze in SD rats.
AIM To investigate whether or not histamine is involved in spatial memory deficits induced by dizocilpine (MK-801) as evaluated by 8-arm radial maze of rats. METHODS 8-Arm (4-arm baited) radial… Expand
Early treatment of minocycline alleviates white matter and cognitive impairments after chronic cerebral hypoperfusion
Subcortical ischemic vascular dementia (SIVD) caused by chronic cerebral hypoperfusion develops with progressive white matter and cognitive impairments, yet no effective therapy is available. We… Expand