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MicroRNA-148a-3p enhances cisplatin cytotoxicity in gastric cancer through mitochondrial fission induction and cyto-protective autophagy suppression.
Cisplatin (CDDP) resistance is a major clinical problem associated with poor prognosis in gastric cancer (GC) patients. In this study, we performed integrated analysis of TCGA data from microRNAsExpand
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Detection of circulating gastric carcinoma‐associated antigen MG7‐Ag in human sera using an established single determinant immuno‐polymerase chain reaction technique
In 1994, a novel sensitive method termed immuno‐polymerase chain reaction (PCR) for the detection of the gastric carcinoma‐associated antigen MG7‐Ag in the gastric carcinoma cell line KATO III wasExpand
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Transcriptional program of Kpna2/Importin-α2 regulates cellular differentiation-coupled circadian clock development in mammalian cells
Significance The emergence of the cell-autonomous circadian oscillator is coupled with cellular differentiation. Cellular differentiation, as well as reprogramming, results in global alterations ofExpand
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Guidelines for Genome-Scale Analysis of Biological Rhythms
Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and metabolites,Expand
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Gastric adenocarcinoma has a unique microRNA signature not present in esophageal adenocarcinoma
MicroRNAs (miRNAs) play critical roles in tumor development and progression. The finding that a single miRNA can regulate hundreds of genes places miRNAs at critical hubs of signaling pathways. ForExpand
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Helicobacter pylori-induced cell death is counteracted by NF-κB-mediated transcription of DARPP-32
Objective DARPP-32 is a frequently amplified and overexpressed gene that promotes several oncogenic functions in gastric cancer. Herein, we investigated the relationship between Helicobacter pyloriExpand
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Gastric tumour-derived ANGPT2 regulation by DARPP-32 promotes angiogenesis
Objective Overexpression of dopamine and cAMP-regulated phosphoprotein, Mr 32000 (DARPP-32), and its truncated isoform (t-DARPP) are associated with gastric tumorigenesis. Herein, we investigated theExpand
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TG2 and NF-κB Signaling Coordinates the Survival of Mantle Cell Lymphoma Cells via IL6-Mediated Autophagy.
Expression of the transglutaminase TG2 has been linked to constitutive activation of NF-κB and chemotherapy resistance in mantle cell lymphoma (MCL) cells. TG2 forms complexes with NF-κB components,Expand
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Relationship between NF-κB, MMP-9, and MICA expression in pituitary adenomas reveals a new mechanism of pituitary adenomas immune escape
The aim of this study was to examine the expression levels of NF-κB, MMP-9, and MICA and their relationship between each other in pituitary adenomas as a histological basis for the study of theExpand
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Eriocalyxin B ameliorates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells
  • Y. Lu, B. Chen, +11 authors S-J Chen
  • Medicine
  • Proceedings of the National Academy of Sciences
  • 23 January 2013
Eriocalyxin B (EriB), a diterpenoid isolated from Isodon eriocalyx, was previously reported to have antitumor effects via multiple pathways, and these pathways are related to immune responses. InExpand
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