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A mechanism for Wnt coreceptor activation.
TLDR
This study identifies a critical signaling module and a key phosphorylation-dependent activation step of the Wnt receptor complex and reveals a unifying logic for transmembrane signaling by Wnts, growth factors, and cytokines. Expand
Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics
TLDR
A new VPS9-domain protein with ankyrin repeats, the V PS9-ankyrin-repeat protein (Varp), which interacts preferentially with GDP-bound Rab21 and has a much stronger guanine nucleotide exchange activity towards Rab21 than Rab5. Expand
ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer
TLDR
It is demonstrated for the first demonstration that ADAMTS9 is a critical tumor suppressor of gastric cancer progression at least in part through suppression of oncogenic AKT/mTOR signaling. Expand
Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity.
TLDR
It is shown that ALCAT1, a lyso-CL acyltransferase upregulated by oxidative stress and diet-induced obesity (DIO), catalyzes the synthesis of CL species that are highly sensitive to oxidative damage, leading to mitochondrial dysfunction, ROS production, and insulin resistance. Expand
hSef Inhibits PC-12 Cell Differentiation by Interfering with Ras-Mitogen-activated Protein Kinase MAPK Signaling*
TLDR
The data suggested Sef exerted the negative effect on FGF2-induced PC-12 cell differentiation through the prevention of Ras-mitogen-activated protein kinase signaling, possibly functioning upstream of the Ras molecule. Expand
Smad1 Interacts with Homeobox DNA-binding Proteins in Bone Morphogenetic Protein Signaling*
TLDR
Findings suggest that Smad1 interaction with Hoxc-8 dislodges HoxC-8 from its DNA binding element, resulting in the induction of gene expression. Expand
CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes.
TLDR
A gene CREPT is reported that is preferentially expressed in diverse human tumors and a mechanism where CREPT increases cyclin D1 transcription during tumorigenesis is revealed, through enhancing the recruitment of RNAPII to the promoter region, possibly as well as chromatin looping. Expand
Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer
TLDR
PTPMeg2 is an important phosphatase for the dephosphorylation of STAT3 and plays a critical role in breast cancer development. Expand
Smad Ubiquitylation Regulatory Factor 1/2 (Smurf1/2) Promotes p53 Degradation by Stabilizing the E3 Ligase MDM2*
TLDR
This is the first report to demonstrate that Smurf1/2 functions as a factor to stabilize MDM2 protein rather than as a direct E3 ligase in regulation of p53 degradation. Expand
Varp interacts with Rab38 and functions as its potential effector.
TLDR
This study demonstrates that Varp physically interacts with Rab38, and preferentially binds to the active GTP-bound form of Rab38 both in vitro and in vivo, and proposes Varp serves as both an effector and a GEF by interacting with different Rabs in mammalian cells. Expand
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