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Induction of endothelial cell apoptosis by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid
- L. Ching, Z. Cao, C. Kieda, S. Zwain, M. Jameson, B. Baguley
- British Journal of Cancer
- 17 June 2002
It is concluded that 5,6-Dimethylxanthenone-4-acetic acid can induce vascular endothelial cell apoptosis in some murine and human tumours and appears to be independent of tumour necrosis factor induction. Expand
Stimulation of tumors to synthesize tumor necrosis factor-alpha in situ using 5,6-dimethylxanthenone-4-acetic acid: a novel approach to cancer therapy.
- W. Joseph, Z. Cao, K. Mountjoy, E. Marshall, B. Baguley, L. Ching
- Cancer research
- 1 February 1999
It is shown here that the extent of DMXAA-induced TNF synthesis is greater in tumors than that in the spleen, liver, or serum, and the use of low molecular weight agents to induce T NF synthesis in situ in the tumor represents a novel approach to TNF-mediated therapy of cancers. Expand
Interferon-inducible protein 10 induction and inhibition of angiogenesis in vivo by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).
The hypothesis that DMXAA, in addition to antivascular effects mediated by tumor necrosis factor-alpha, may have an antiangiogenic effect mediated largely by the induction of IP-10 is supported. Expand
Thalidomide increases both intra-tumoural tumour necrosis factor-α production and anti-tumour activity in response to 5,6-dimethylxanthenone-4-acetic acid
Co-administration of thalidomide may represent a novel approach to improving selective intra-tumoural TNF-α production and anti-Tumour efficacy of DMXAA. Expand
Antitumour activity of the novel immune modulator 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice lacking the interferon-gamma receptor.
- J. Pang, Z. Cao, W. Joseph, B. Baguley, L. Ching
- Biology, Medicine
- European journal of cancer
- 1 July 1998
The results demonstrate that the host response to IFN-gamma is not essential for an anti-tumour response and are consistent with the concept that the antitumour activity of DMXAA involves complex immunomodulation, probably with significant redundancy in contributing cytokines. Expand
Effect of Artesunate on the Expression of ICAM-1 and MMP-9 in Vascular Endothelial Cells under High Glucose Condition
Objective: To investigate the effect of ART on the expression of ICAM-1 and MMP-9 in vascular endothelial cells under high glucose condition. Methods: Human Umbilical Vein Endothelial Cells (HUVEC)… Expand
Inhibitory effect of Telmisartan on STZ-induced early retinopathy in diabetic mice
To investigate the effect of Telmisartan intravitreal injection on diabetic retinopathy and its protective mechanism. 54 adult male C57B/6L mice were included in this study. All the mice were… Expand