• Publications
  • Influence
TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease.
  • B. Willis, Z. Borok
  • Medicine, Biology
    American journal of physiology. Lung cellular and…
  • 2007
TLDR
It is hoped that this review will stimulate further consideration of the cellular mechanisms of fibrogenesis in the lung and especially the role of the epithelium in this process, potentially leading to innovative avenues of investigation and treatment.
TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease
TLDR
It is hoped that this review will stimulate further consideration of the cellular mechanisms of fibrogenesis in the lung and especially the role of the epithelium in this process, potentially leading to innovative avenues of investigation and treatment.
Epithelial origin of myofibroblasts during fibrosis in the lung.
TLDR
It is hoped that a major shift in current paradigms regarding the genesis of pulmonary fibrosis and dissection of the relevant pathways may allow development of targeted interventions that could potentially reverse the process and ameliorate the debilitating effects of abnormal repair and progressive fibrosis.
Wnt5a participates in distal lung morphogenesis.
TLDR
It is shown that Wnt5a is expressed in the mouse lung and plays an important role in lung distal morphogenesis and the overall architecture of the mutant lungs is characterized by overexpansion of the distal airways and inhibition of lung maturation as reflected by persistence of thickened intersaccular interstitium.
Pulmonary Langerhans Cell Granulomatosis (Histiocytosis X) A Clinicopathologic Study of 48 Cases
TLDR
The frequent finding of intraluminal fibrosis and the frequent peribronchiolar location of PLCG lesions are consistent with the concept that in adults this disorder is associated with an abnormal response to cigarette smoke.
Interactions Between β-Catenin and Transforming Growth Factor-β Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response
TLDR
TGF-β induction of α-smooth muscle actin (α-SMA) involves ternary complex formation among Smad3, β-catenin, and CBP, which suggests a new therapeutic approach to pulmonary fibrosis by specifically uncoupling CBP/ catenin-dependent signaling downstream of TGF- β.
Systemic deficiency of glutathione in cystic fibrosis.
TLDR
It is hypothesized that glutathione in respiratory epithelial lining fluid (ELF) in CF patients might be oxidized and/or diminished in amount compared with that in normal subjects and observed marked neutrophil-dominated inflammation in ELF inCF patients.
Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells.
TLDR
Foxj1 functions in late-stage ciliogenesis to regulate programs promoting basal body docking and axoneme formation in cells previously committed to the ciliated cell phenotype.
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