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Flexible use of nuclear import pathways by HIV-1.
TLDR
A fragment of the cleavage and polyadenylation factor 6, CPSF6, is identified as a potent inhibitor of HIV-1 infection and highlights a single residue in CA as essential in regulating interactions with NUPs. Expand
A macaque model of HIV-1 infection
TLDR
Simian-tropic (st)HIV-1 strains that differ from HIV-1 only in the vif gene are constructed that are capable of high levels of replication in vitro in pig-tailed macaque lymphocytes and demonstrate the potential utility in a chemoprophylaxis experiment. Expand
Human Immunodeficiency Virus Type 1 Capsid Mutation N74D Alters Cyclophilin A Dependence and Impairs Macrophage Infection
TLDR
Compared to wild-type (WT), N74D HIV-1 is more sensitive to cyclosporine, has increased sensitivity to nevirapine, and is impaired in macrophage infection prior to reverse transcription, which suggests a difference in the N 74D reverse transcription complex that manifests early after infection and prior to interaction with the nuclear pore. Expand
HIV/AIDS: in search of an animal model.
TLDR
The uses and limitations of existing models and recent advances that might lead to better animal models for HIV/AIDS are discussed. Expand
HIV-1 uncoating: connection to nuclear entry and regulation by host proteins.
TLDR
Understanding uncoating will be valuable toward developing novel antiretroviral therapies for HIV-infected individuals, particularly with respect to nuclear import pathways and protection of the viral genome from DNA sensors. Expand
The nucleoside analogue D-carba T blocks HIV-1 reverse transcription.
TLDR
D-carba T effectively inhibits viral vectors that replicate using NRTI-resistant HIV-1 RTs, and there is no obvious toxicity in cultured cells, suggesting NRTIs based on the carbocyclic pseudosugar may offer an effective approach for the treatment of HIV- 1 infections. Expand
Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay
TLDR
A novel RNA accessibility-based assay that detects an early event in HIV-1 uncoating and can be used to further define this process is established. Expand
Genetic Diversity of Simian Immunodeficiency Virus Encoding HIV-1 Reverse Transcriptase Persists in Macaques despite Antiretroviral Therapy
TLDR
Findings indicate that viral diversity does not decrease with suppressive ART, that ongoing replication occurs with viremias >15 copies/ml, and that in this macaque model of ART drug resistance likely emerges as a result of incomplete suppression and preexisting drug resistance mutations. Expand
The Level of Reverse Transcriptase (RT) in Human Immunodeficiency Virus Type 1 Particles Affects Susceptibility to Nonnucleoside RT Inhibitors but Not to Lamivudine
TLDR
Data indicate that the susceptibility of HIV-1 to NNRTIs is influenced by RT activity, which is inversely proportional to the level of enzymatically active RT. Expand
Direct visualization of HIV-1 with correlative live-cell microscopy and cryo-electron tomography.
TLDR
Structural analysis of HIV-1 and host-cell interactions by means of a correlative high-speed 3D live-cell-imaging and cryoET method and direct evidence to suggest that a hyperstable mutant capsid, E45A, showed delayed capsid disassembly compared to the wild-type capsid is reported. Expand
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