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Anti-Inflammatory and Neuroprotective Effects of Constituents Isolated from Rhodiola rosea
Rhodiola rosea may have therapeutic potential for the treatment of inflammation and neurodegenerative disease and the level of phosphorylated MAPK, pJNK, and pp38 was increased by L-glutamate treatment but decreased by the treatment with rosin and salidroside. Expand
Phytochemical investigation of Turnera diffusa.
A phytochemical investigation of Turnera diffusa afforded 35 compounds, comprised of flavonoids, terpenoids, saccharides, phenolics, and cyanogenic derivatives, including five new compounds (1-5) andExpand
Phenylalkanoids and monoterpene analogues from the roots of Rhodiola rosea.
Phytochemical investigation of the roots of Rhodiola rosea afforded 17 compounds, belonging to the phenylalkanoids and monoterpene analogues, which were determined by spectroscopic and chemical methods. Expand
The effect of Salvia divinorum and Mitragyna speciosa extracts, fraction and major constituents on place aversion and place preference in rats.
These findings suggest that both botanicals possess liabilities, albeit somewhat different, that warrant caution in their use. Expand
Comparison of three chromatographic techniques for the detection of mitragynine and other indole and oxindole alkaloids in Mitragyna speciosa (kratom) plants.
The observed lack of resolution of the indole alkaloid diastereoisomers coupled with the likeness of the mass and tandem mass spectra calls into question proposed GC methods for the analysis of mitragynine based on solely GC with MS separation and identification. Expand
Evaluation of in vitro absorption, distribution, metabolism, and excretion (ADME) properties of mitragynine, 7-hydroxymitragynine, and mitraphylline.
Evaluating the absorption, distribution, metabolism, and excretion (ADME) properties of these compounds and their effect on major efflux transporter P-glycoprotein, using in vitro methods indicates the possibility of a drug interaction if mitragynine and 7-hydroxymitragynines are coadministered with drugs that are P- glycoprotein substrates. Expand
Effect of green tea and its polyphenols on mouse liver.
This study confirms the safety of reasonable consumption of GT over a short term, however, it highlights a caution that high doses of EGCG can lead to mild liver injury, and this may be markedly enhanced under febrile conditions. Expand
Constituents from Terminalia species increase PPARα and PPARγ levels and stimulate glucose uptake without enhancing adipocyte differentiation.
ETHNOPHARMACOLOGICAL RELEVANCE The fruits of Terminalia bellerica Roxb. (Combretaceae) and T. chebula Retz. (Combretaceae) are important components of triphala, a popular Ayurvedic formulation, forExpand
PXR mediated induction of CYP3A4, CYP1A2, and P‐gp by Mitragyna speciosa and its alkaloids
Results indicate that high consumption of Mitragyna speciosa extract along with the conventional drugs may lead to potential herb–drug interactions due to its effects on PXR. Expand