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Role of hypothalamic factors (growth-hormone-releasing hormone and gamma-aminobutyric acid) in the regulation of growth hormone secretion in the neonatal and adult rat.
The results indicate that GH secretion is partly regulated by endogenous GRH in the newborn rat but that the elevation of plasma GH levels after GABA is not mediated by GRH.
gamma-Aminobutyric acid stimulates pituitary growth hormone secretion in the neonatal rat. A superfusion study.
The results indicate that in the postnatal period the regulation of GH secretion differs from that of the adult animal and GABA might play an important role in the maintenance of the high GH secretion during the first days of life.
Site of γ-aminobutyric acid (GABA)-mediated inhibition of growth hormone secretion in the rat
The effect of altering γ-aminobutyric acid (GABA) activity on growth hormone (GH) secretion of freely moving chronically cannulated male rats was studied. Systemic injection of the GABA agonist muscim
Site of gamma-aminobutyric acid (GABA)-mediated inhibition of growth hormone secretion in the rat.
Results are consistent with the hypothesis that GABAergic tonic inhibition participates in the control of GH secretion and that GABA inhibits spontaneous GH release by inhibiting the secretion of a GH-releasing factor.
Effect of cortexolone on the feedback action of dexamethasone
Cortexolone in a dose of 1 mg/100 g body wt., administered to rats prior to dexamethasone, prevented dexamethasone from suppressing stress-induced ACTH-release without interfering with the effect of
The hypophyseal-adrenocortical response to various different stressing procedures in ACTH-treated rats.
It would appear that it is the high corticosterone level produced by the last ACTH injection that suppresses the corticotrophin-releasing factor (CRF) 24 hours later (feedback action) when this level returns to normal or less than normal; and that certain stressors liberate CRF whereas others do not.
Zonal differences in the distribution and morphology of lipid droplets using 4-amino-pyrazolo-(3,4 d) pyrimidine to lower cholesterol level in the rat adrenal.
The data suggest that reduced blood and adrenal cholesterol levels do not affect lipids located in the zona glomerulosa and in the inner cortical zones in the same way, probably due to differences in their intracellular lipid dynamism.
Evidence is provided that the human foetal adrenal possesses the potentiality to secrete hydrocortisone, and the humanfoetal hypophysis continues to produce ACTH at a low level without stimulation by the hypothalamus, at least for some time.
An extra-adrenal effect of corticotrophin.