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The Prader-Willi syndrome (PWS)/Angelman syndrome (AS) region, on human chromosome 15q11-q13, exemplifies coordinate control of imprinted gene expression over a large chromosomal domain. Establishment of the paternal state of the region requires the PWS imprinting center (PWS-IC); establishment of the maternal state requires the AS-IC. Cytosine methylation(More)
To the Editor : We read with great interest the article by Sasa et al. (1) in which they identified three novel truncating mutations in the telomere-associated protein TIN2 in children with an inherited form of bone-marrow failure syndrome known as Dyskeratosis congenita (DC). TIN2 is one of the six protein subunits of the shelterin protein complex that(More)
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