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Role of P-glycoprotein in restricting the brain penetration of tanshinone IIA, a major active constituent from the root of Salvia miltiorrhiza Bunge, across the blood–brain barrier
Tanshinone IIA (TSA) is a major constituent of Salvia miltiorrhiza Bunge widely used in the treatment of stroke. This current study aimed to investigate the nature of brain penetration of TSA usingExpand
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Clinical drugs undergoing polymorphic metabolism by human cytochrome P450 2C9 and the implication in drug development.
CYP2C9 metabolizes more than 100 clinically used drugs including phenytoin, S-warfarin, tolbutamide, glipizide, diclofenac, and losartan with varying contributions. CYP2C9 is considered one of theExpand
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PI-3K/AKT signal pathway modulates vascular smooth muscle cells migration under cyclic mechanical strain.
BACKGROUND The migration of vascular smooth muscle cells (VSMCs), exposed to altered mechanical strain, contributes to vascular remodeling which is the key event underlying the pathogenesis ofExpand
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Role of ATP-binding cassette drug transporters in the intestinal absorption of tanshinone IIB, one of the major active diterpenoids from the root of Salvia miltiorrhiza
  • X-Y Yu, Z-W Zhou, +7 authors S. Zhou
  • Chemistry, Medicine
  • Xenobiotica; the fate of foreign compounds in…
  • 1 April 2007
There is an increasing use of herbal medicines worldwide, and the extracts from the root of Salvia miltiorrhiza are widely used in the treatment of angina and stroke. In this study, we investigatedExpand
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Validation of a nomogram for selecting patients for chemotherapy after D2 gastrectomy for cancer
According to some guidelines for the management of gastric cancer, adjuvant chemotherapy is recommended for patients with pT3–4 or node‐positive disease. The aim of this study was to define low‐ andExpand
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Imatinib-induced ophthalmological side-effects in GIST patients are associated with the variations of EGFR, SLC22A1, SLC22A5 and ABCB1
Imatinib-induced ophthalmological side-effects, including conjunctiva hemorrhage and periorbital oedema, although very common and still remain relatively little understood. The present studyExpand
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