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1. In order to characterize the thermoregulatory actions of brain neuropeptide Y (NPY), the effects of intra-third ventricular (I3V) injection of NPY on temperatures of colon (Tco), brown adipose tissue (TBAT) and tail skin (Ts) were observed at ambient temperatures (Ta) of 19 and 8 degrees C. 2. The injection of NPY in a dose of 8 mcg/100 g body wt evoked(More)
1. In order to better delineate the profile of thermoregulatory action of alpha 1-adrenoceptor antagonists; corynanthine (CRN) and BMY 20064 (BMY), and alpha 2-adrenoceptor agonist; medetomidine (MDT) and B-HT 920 (BHT), the effect of intravenous administration of two doses of these drugs on rectal (Tre) and ear skin (Te) temperatures, metabolic rate (M),(More)
Thermoregulatory responses after treatment with nitric oxide (NO) donor, sodium nitroprusside (SNP-3 mg/kg/h), or NO synthase inhibitor, NG-nitro-L-arginine methylester (L-NAME-100 mg/kg) were investigated in febrile rabbits (lipopolysaccharide E. coli-1 meg/kg). Pretreatment with SNP attenuated pyrogen fever as well as metabolic rate. L-NAME also inhibited(More)
1. The thermoregulatory, effector processes were investigated after treatment with prazosin (PRA), dihydrobenzperidol (DHBP) and nifedipin (ADA) applied to the thermosensitive zone of the anterior hypothalamus (PO/AH) on normothermic and feverish rabbits (LPS, lipopolysaccharide E. coli; 1 meg/kg, i.v.). 2. The alpha 1-noradrenergic receptor antagonists,(More)
1. Thermoregulatory effector processes were investigated in rabbits after treatment with 1 and 2 micrograms/kg of lipopolysaccharide Escherichia coli (LPS). Both doses produced a fever reaction resulting from stimulation of the metabolic rate and heat conservation responses. 2. BE 2254 administered in feverish rabbits reduced the metabolic as well as(More)
1. Thermal responses to i.v. administration of doxazosin (0.75 or 1.50 mg/kg), urapidil (5.0 or 10.0 mg/kg), or indoramin (0.75 or 1.50 mg/kg) were investigated in febrile rabbits (treated with Escherichia coli lipopolysaccharide) at an ambient temperature of 19 +/- 1 degree C. 2. All these alpha 1-adrenoceptor blockers produced statistically significant(More)
An attempt was made to study the influence of prazosin on thermoregulatory parameters. Two sets of experiments were carried out in rabbits. In the first set of experiments prazosin was given as 3 h infusion intravenously, (iv) (0.1, 0.25 and 0.5 mg/kg/h) or intracerebroventricularly, (icv) (20, 50 and 100 micrograms/animal) at an ambient temperature of 22(More)
1. Thermal responses to prazosin (0.75 mg/kg; i.v.), dihydrobenzperidol (0.75 mg/kg or 2.25 mg/kg; i.v.), nifidepine (0.05 mg/kg or 0.16 mg/kg; i.v.) administered in the form of bolus injection or infusion were investigated in febrile rabbits. 2. Pyrogen (Escherichia coli lipopolysaccharide, LPS, 1 mcg/kg; i.v.) produced a fever reaction resulting from(More)
1. Thermoregulatory responses to BHT 920, prazosin (PRA) and 6-hydroxydopamine (6-OHDA) were investigated in pyrogen (lipopolysaccharide Escherichia coli, LPS) treated rabbits. 2. All the compounds in question, despite their different selectivity for pre- or postsynaptic adrenergic structures, significantly reduced pyrogen fever. Antipyresis was associated(More)