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Thymidylate synthase (TS) catalyzes the transfer of a methyl group from methylenetetrahydrofolate to dUMP to form dTMP. It is a primary target in the chemotherapy of colorectal cancers and some other neoplasms. In order to obtain pure protein for analysis of structure and biological function, an expression vector TS-pET28b (+) was constructed by inserting(More)
Mutagenic effect of polycyclic aromatic hydrocarbon (PAH)-DNA adduct was studied to explore mechanism of carcinogenecity of PAH. Adduct was formed by chemical group protection and nucleophilic displacement methods with modification of deoxyadenosine by PAH-dihydrodiol epoxide. Partial analogous sequence of human protooncogene ras (H-ras) containing(More)
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