Z Mroczkowski

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Several radiosensitizing chemicals, including a family of simple nitroimidazoles, were examined in E. coli and compared with misonidazole for toxic side-effects on endpoints such as mutagenesis, cell killing and inhibition of the synthesis of the inducible enzyme beta-galactosidase. While all the compounds were similar to misonidazole or better in(More)
The mutagenic and toxic effects of the nitroimidazole hypoxic cell sensitizer misonidazole (Ro-07-0582) have been studied in two strains of E. coli that differ in their abilities to repair DNA. It was found that even though the strain defective in excision repair was only slightly more sensitive than the original wild-type strain to killing by misonidazole,(More)
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