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We monitored survival of Purkinje cells in rat cerebellar slices to test the hypothesis that isoflurane preconditioning reduces ischemia-induced neuronal death. Preconditioning the brain slices with isoflurane, a volatile anesthetic commonly used in clinical practice, at 1-4% for 15 min at 37 degrees C significantly decreased Purkinje cell injury and death(More)
We present a rare case in which a healthy parturient developed a paraspinal abscess after spinal anaesthesia for caesarean section and epidural analgesia for postoperative pain management. The catheter was in situ for 58 h. Backache was the initial and major symptom. A concealed course with no neurological deficit resulted in a delayed diagnosis and(More)
We showed that hypothermic preconditioning (HPC) increased survival of Purkinje neurons in rat cerebellar slices after oxygen-glucose deprivation (OGD). HPC also reduced the OGD-increased expression of high mobility group I (Y) proteins, a transcription factor that can enhance inducible nitric oxide synthase (iNOS) expression. iNOS is a putatively damaging(More)
BACKGROUND 'Obesity paradox' was not consistently observed in Asians with coronary artery disease (CAD). AIM The study investigated the association between body composition and outcomes in Chinese patients with CAD. DESIGN Cohort study. METHOD A total of 3280 patients with angiographically validated CAD were consecutively included. Body fat (BF)(More)
BACKGROUND There is debate regarding the predictive value of interventricular septum (IVS) wall thickness for adverse events. AIMS The study investigated the association between the severity of thickened IVS and all-cause death in Chinese patients with coronary artery disease (CAD). METHODS A total of 2297 CAD patients verified by angiography was(More)
OBJECTIVE To explore whether nutritional risk is associated with poor outcomes independent of complicated clinical status in older patients with coronary artery disease (CAD). DESIGN Cohort study. SETTING Patients referred for coronary angiography in West China Hospital, Sichuan University, China. PARTICIPANTS 1772 patients with angiographic(More)
BACKGROUND Isoflurane decreases ischemia-induced neuronal injury. The mechanisms of this effect are largely unknown. We hypothesize that isoflurane induces expression of protective stress genes and decreases expression of apoptosis-related genes. METHODS The mRNA expression of about 1300 genes related to neurobiology in rat glial-neuronal cocultures was(More)
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