Learn More
Leukotrienes (LTs) C4 or D4 in a dose of 12 nmoles were administered into the lateral ventricle (i.c.v.) of the rat brain under urethane anaesthesia, and the changes in the blood pressure, heart and respiratory rate were investigated. In other animals the behaviour was evaluated by means of the open field test, and the rectal body temperature was measured.(More)
PGI2 1 or 10 micrograms iv caused a decrease of blood pressure and bradycardia in rats. PGI2 administered into lateral ventricle of rat brain [icv] exerted hypotensive effect and tachycardia. PGI2 10 micrograms icv increased histamine level in the hypothalamus and cortex of rat's brain, but it did not influence histamine content in the blood. Cimetidine(More)
The influence of verapamil on cardiovascular effects of prostacyclin (PGI2) in rats was examined. PGI2 administered into the lateral brain ventricle (i.c.v.) or intravenously (i.v.) in a dose of 2.7 x 10(-8)mol evoked hypotension and tachycardia. Pretreatment with verapamil in a dose of 2.0 x 10(-5)mol/kg given intraperitoneally (i.p.) diminished(More)
Prostacyclin (PGI2) administered icv into the lateral rat brain ventricle in a dose of 1 and 10 micrograms caused hypothermia and catalepsy. Joint administration of PGI2 and chlorpromazine produced a greater cataleptic effect than that observed after the neuroleptic alone. Cimetidine (CMT) 2 g/kg po administered 60 min before PGI2 icv injection inhibited(More)
D-Ala2-met-enkephalinamide (DAMEA) in ethyl urethane anesthetised rats increased the blood pressure, decreased heart rate and frequency of respirations. DAMEA could act centrally as well as peripherally after the penetration from the cerebro-spinal into the blood stream. These effects were blocked by naloxone. 6-Hydroxydopamine inhibited the circulatory and(More)
Prostacyclin (PGI2) administered i.c.v. into the lateral rat brain ventricle in a dose of 1 and 10 micrograms causes hypothermia, catalepsy as well as a mild analgesic effect. Joint administration of PGI2 along with chloropromazine or morphine produces a greater cataleptic effect than that observed after application of neuroleptics and morphine alone.(More)
The effects of optical isomers of fenfluramine and their metabolites, d- and l-norfenfluramine on the serotonergic system were studied in the nucleus accumbens and hippocampus of freely moving rats by in vivo voltammetry. Both isomers and the metabolites induced a slow, sustained decrease in 5HIAA but only d-fenfluramine and its metabolite,(More)
In rats with central chemical sympathectomy induced by two injections into the lateral brain ventricle (icv) of 250 micrograms of 6-hydroxydopamine or with central chemical serotoninectomy induced by 75 micrograms of 5,6-dihydroxytryptamine icv the antinociceptive and behavioral effects of LENK (200 micrograms icv) or DAMEA (10 or 20 micrograms icv) were(More)
  • 1