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OBJECTIVE The ventrolateral nucleus of the thalamus (VL), based on its connectivity with the cerebellum and motor cortex, has long been considered to be involved with motor functions. We show that the human VL also plays a prominent role in sensory processing. METHODS Structural magnetic resonance imaging and diffusion tensor imaging were used to localize(More)
An efficient, high-order, conservative method named the spectral difference method has been developed recently for conservation laws on unstructured grids. It combines the best features of structured and unstructured grid methods to achieve high-computational efficiency and geometric flexibility; it utilizes the concept of discontinuous and high-order local(More)
Eight children with moderate to severe traumatic brain injury (TBI) and eight matched, uninjured control children underwent fMRI during an N-back task to test effects of TBI on working memory performance and brain activation. Two patterns in the TBI group were observed. Patients whose criterion performance was reached at lower memory loads than control(More)
In dynamic susceptibility contrast MRI, the shape of the arterial input function (AIF) is commonly obtained in the near vicinity of the middle cerebral artery (MCA). However, the tissue regions where the AIF is sampled also have significant perfusion, which contributes to T(2)* changes. We investigate whether correction of this effect will introduce(More)
Alterations in cerebrovascular function are evident acutely in moderate to severe traumatic brain injury (TBI), although less is known about their chronic effects. Adolescent and adult patients with moderate to severe TBI have been reported to demonstrate diffuse activation throughout the brain during functional magnetic resonance imaging (fMRI). Because(More)
BACKGROUND Despite normal CT imaging and neurologic functioning, many individuals report postconcussion symptoms following mild traumatic brain injury (MTBI). This dissociation has been enigmatic for clinicians and investigators. METHODS Diffusion tensor imaging tractography of the corpus callosum was performed in 10 adolescents (14 to 19 years of age)(More)