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The masking of antigens by aldehyde-containing fixatives or by paraffin embedding procedures is a problem for immunohistochemical studies. Enzymatic digestion, formic acid treatment, microwave heating and autoclave heating have been used to deal with this problem, with microwave heating-based antigen retrieval having become widely used as the method of(More)
The distribution and cellular localization of dopamine D1A and D1B receptor mRNAs in the forebrain and midbrain of the domestic chick were examined using in situ hybridization histochemistry with 35[S]-dATP labeled oligonucleotide probes, visualized with film and emulsion autoradiography. Labeling for D1A receptor mRNA was intense in the medial and lateral(More)
Graphene's high mobility and Fermi velocity, combined with its constant light absorption in the visible to far-infrared range, make it an ideal material to fabricate high-speed and ultrabroadband photodetectors. However, the precise mechanism of photodetection is still debated. Here, we report wavelength and polarization-dependent measurements of(More)
In adult-onset Huntington's disease (HD), striatal projection neurons are much more vulnerable than striatal interneurons, but even striatal projection neurons show differences in their vulnerability, with the striatal projection neurons projecting to the internal segment of the globus pallidus being the least vulnerable. Previous studies have shown that(More)
The sequence patterns of 11 types of frequently occurring connecting peptides, which lead to a classification of supersecondary motifs, were studied. A database of protein supersecondary motifs was set up. An artificial neural network method, i.e. the back propagation neural network, was applied to the predictions of the supersecondary motifs from protein(More)
In conventional superconductivity, sharp phonon modes (oscillations in the crystal lattice) are exchanged between electrons within a Cooper pair, enabling superconductivity. A critical question in the study of copper oxides with high critical transition temperature (Tc) is whether such sharp modes (which may be more general, including, for example, magnetic(More)
A visible /near-IR optical parametric oscillator (OPO) based on type II phase matching in ?-BaB2 O4 (BBO) is described. Pumped at 355 nm, this OPO covers 410 -2500 nm completely with a single set of standard Nd:YAG cavity optics. The output efficiency is >25 %, the linewidth of the OPO is narrower than 1 -2 cm-1 without the use of gratings or etalons, and(More)
Mitogen-activated protein kinase (MAPK) p38 has been implicated in the pathogenesis of Alzheimer's disease, but the upstream cascade leading to p38 activation has not been elucidated in the disease. In the present study, we focused on mitogen-activated protein kinase kinase 6 (MKK6), one of the upstream activators of p38 MAPK. We found that MKK6 was not(More)
The distribution and cellular localization of GAD65 mRNA in the forebrain and midbrain of domestic chick were examined by in situ hybridization histochemistry with (35)[S]-UTP labeled cRNA probes, using film and emulsion autoradiography. Film autoradiograms showed intense GAD65 labeling in many structures of the basal telencephalon, such as the medial and(More)