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fludarabine-cytotoxicity by threefold (Po0.05) when compared with fludarabine treatment alone. In addition, MX potentiated the therapeutic efficacy of fludarabine as evidenced in HL60 xenografts in nude mice. As shown in Figure 3b and a, moderate sensitivity to fludarabine alone was observed in HL60 xenografts; however, significant inhibition of tumor(More)
Polycomb repressive complex 2 (PRC2) is involved in trimethylation of histone H3 lysine 27 (H3K27), chromatin condensation and transcriptional repression. The silencing function of PRC2 complex is mostly attributed to its intrinsic activity for methylating H3K27. Unlike in B-cell lymphomas, enhancer of zeste homolog 2 (EZH2) mutations in myeloid(More)
Suppression of apoptosis by TP53 mutation contributes to resistance of acute myeloid leukemia (AML) to conventional cytotoxic treatment. Using differentiation to induce irreversible cell cycle exit in AML cells could be a p53-independent treatment alternative, however, this possibility requires evaluation. In vitro and in vivo regimens of the deoxycytidine(More)
Tumor angiogenesis plays a critical role in solid tumor development and metastasis. Increased angiogenesis has been implicated in the pathogenesis of hematologic malignancies. The blood supply to tumors may be provided through a number of mechanisms, including intussusceptive angiogenesis, recruitment of endothelial progenitor cells, vessel co-option and(More)
First-hits in the multi-hit process of leukemogenesis originate in germline or hematopoietic stem cells (HSCs), yet leukemia-initiating cells (LICs) usually have a lineage-committed phenotype. The molecular mechanisms underlying this compartment shift during leukemia evolution have not been a major focus of investigation and remain poorly understood. Here a(More)
OBJECTIVE Adenoviral vectors (Ad) were widely used in gene therapy and study of gene function, but the commonly used serotype 5 adenovirus-based vectors (Ad5) could poorly transduce hematopoietic cells because of low expression of viral receptors on these cells. To overcome this limitation, we developed a retargeting adenovector with a chimeric fiber of Ad5(More)
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