Z. A. Burnashova

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Experiments on rats showed that pulse therapy with prednisolone (100 mg/kg intraperitoneally for 3 days) stimulated urinary excretion of hydroxyproline, increased the content of inorganic phosphorus, promoted the increase in the content of dienic conjugates and catalase activity, and decreased serum levels of MDA and ceruloplasmin. Ten-day treatment with(More)
Experiments in rats with an osteoporosis model induced by the chronic administration of prednisolone (50 mg/kg, p.o., over 14 days) showed that the drug differently affects the lipid peroxidation (LPO) rate and the antioxidant system activity. Xydiphone (45 mg/kg, p.o.) administered over 14 days exhibited a perooxidant action. Dimephosphon (208 mg/kg, p.o.)(More)
The efficacy of monophosphonate dimephosphon and diphosphonate xydiphon was compared by experiments in rats with an osteoporosis model induced by the chronic administration of prednisolone. The glucocorticosteroid decreased the total density of trabecules (in both bone and cartilage tissues) in histological micropreparations of lumbar vertebrae and reduced(More)
The parameters of mineral metabolism, a lipid peroxidation (LPO) process, and the efficacy of antioxidant enzyme preparations were studied in rats with an osteoporosis model induced by the administration of prednisolone in a daily dose of 100 mg/kg (i.p.) over 3 days, which is analogous to a pulsed therapy schedule in clinics. The treatment with(More)
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