Yvonne Reinders

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Inter-cellular communication with stromal cells is vital for cancer cells. Molecules involved in the communication are potential drug targets. To identify them systematically, we applied a systems level analysis that combined reverse network engineering with causal effect estimation. Using only observational transcriptome profiles we searched for paracrine(More)
Abbreviations 1D One-dimensional 1 H Hydrogen-1 (proton) 2D Two-dimensional 13 C Carbon-13 31 P Phosphorus-31 ADPKD Autosomal dominant polycystic kidney disease Acetyl-CoA Acetyl coenzyme A ANOVA Analysis of variance ATP Adenosine triphosphate BHBA Beta-hydroxybutyric acid °C Degrees Celsius Ca Calcium ck Choline kinase CPMG Carr, Purcell, Meiboom, Gill DIM(More)
The ability of plants to serve as a production system for bacterial lipoprotein vaccines has been investigated. First, the effect of high-level expression of the Borrelia burgdorferi outer membrane protein A (OspA), a prototype vaccine against Lyme disease, has been examined by a proteomics approach. Analysis by 2D-PAGE of wild type tobacco plants and(More)
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