Yvonne P. Dragan

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BACKGROUND Proteomic profiling of complex biological mixtures by the ProteinChip technology of surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry (MS) is one of the most promising approaches in toxicological, biological, and clinic research. The reliable identification of protein expression patterns and associated(More)
BACKGROUND The completion of the sequencing of human, mouse and rat genomes and knowledge of cross-species gene homologies enables studies of differential gene expression in animal models. These types of studies have the potential to greatly enhance our understanding of diseases such as liver cancer in humans. Genes co-expressed across multiple species are(More)
BACKGROUND Fibrates are a unique hypolipidemic drugs that lower plasma triglyceride and cholesterol levels through their action as peroxisome proliferator-activated receptor alpha (PPARalpha) agonists. The activation of PPARalpha leads to a cascade of events that result in the pharmacological (hypolipidemic) and adverse (carcinogenic) effects in rodent(More)
The rapid advances in proteomic analyses coupled with the completion of multiple genomes have led to an increased demand for determining protein functions. The first step is classification or prediction into families. A method was developed for the prediction of protein family based only on protein sequence using support vector machine (SVM) models. In(More)
Tamoxifen has found extensive use in the treatment of all stages of human breast cancer. The efficacy of tamoxifen treatment for the pre vention of second primary tumors and Its chemosuppressive action In animal models have led to Initiation ofclinical trials to test its emeacy for prevention of this disease In women. Recently, tamoxifen has been shown to(More)
There is shown the cause and effect of some kind bifurcation and even dissociation of physicists fhinking which have been provoked by pandomination of so-called general relativity theory. A system analysis of invariance concept and term origination instead of relativity ones and real perceiving of physical laws symmetry for investigations and its necessity(More)
Russia # The views expressed in this paper are those of the authors and do not represent FDA policy 2 Abstract We describe a novel approach to the analysis of toxicogenomics data and elucidation of biological networks affected by drug treatments. In this method approximately 15,000 linear pathway modules were generated from manually assembled pathway maps(More)
In many branches of the human activity is actual extraction of the information carried by signals. At the yielding of the information the essential role plays the processing of the signal. The developing of the algorithm of signal processing follow the act of specifying - a detailed, itemized descriptions of the signal, named specification of the algorithm.(More)
The given work is devoted for developing based on a reproducing kernel Hilbert space (RKHS) methodics to the rigged Hilbert space (RHS) obtained from a Hilbert space over Hilbert Space (HSOHS). Are obtained an analog to digital conversion (ADC) of a signal with the spectrum spreaded in the wide band representation and accuracy inner product. Furthermore, we(More)