Yvonne M. W. Janssen-Heininger

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Muscle wasting is often associated with chronic inflammation. Because tumor necrosis factor α (TNF-α) has been implicated as a major mediator of cachexia, its effects on C2C12 myocytes were examined.(More)
Pulmonary inflammation in asthma is orchestrated by the activity of NF-kappaB. NO and NO synthase (NOS) activity are important modulators of inflammation. The availability of the NOS substrate,(More)
Transforming growth factor (TGF)-β1 is a key mediator of lung remodeling and fibrosis. Epithelial cells are both a source of and can respond to TGF-β1 with epithelial-to-mesenchymal transition (EMT).(More)
Muscle wasting accompanies diseases that are associated with chronic elevated levels of circulating inflammatory cytokines and oxidative stress. We previously demonstrated that tumor necrosis(More)