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Although great effort has been put forth to uncover the complex molecular mechanisms exploited in the pathogenesis of Parkinson's disease, a satisfactory explanation remains to be discovered. The emergence of several -omics techniques, transcriptomics, proteomics and metabolomics, have been integral in confirming previously identified pathways that are(More)
Systemic delivery of AAV9 offers the potential for widespread and efficient gene delivery to the retina, and may thus be a useful approach for treatment of disease where intraocular injections are not possible, for syndromes affecting multiple organs, or where early intervention is required. The expression resulting from intravenous injection of AAV9 is(More)
Many wingless insects perform directed aerial descent (DAD) to return to vegetational structures after falling. Given the complex visual environment and spatial structures of tree canopies, those visual signals used as directional cues are not fully understood. Here, we address the role of visual contrast for DAD in newly hatched nymphs of the stick insect(More)
Many wingless insects perform directed aerial descent (DAD) to return to vegetational structures after falling. Given the complex visual environment and spatial structures of tree canopies, those visual signals used as directional cues are not fully understood. Here, we address the role of visual contrast for DAD in newly hatched nymphs of the stick insect(More)
Previous investigations using several species of invertebrates have indicated a correlation between nuclear chromocentre content and the ability to regenerate. Such findings have resulted in the formulation of the hypothesis that the ability to regenerate may be dependent on cellular heterochromatin content. In order to test this concept further, a number(More)
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