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An Independent Subset of TLR Expressing CCR2-Dependent Macrophages Promotes Colonic Inflammation
The balance between proinflammatory and resident Mϕs in the colon is controlled by CCR2-dependent recruitment mechanisms, which could prove useful as targets for therapy in inflammatory bowel disease.
The Atypical Chemokine Receptor D6 Contributes to the Development of Experimental Colitis 1
It is shown that D6 is expressed in the resting colon, predominantly by stromal cells and B cells, and is up-regulated during colitis, and can contribute to the development of colitis by regulating IL-17A secretion by γδ T cells in the inflamed colon.
Macrophages: Innate memory training
Epigenetic remodelling and changes in cellular metabolism are required for memory-like responses in innate immune cells and these changes need to be controlled by Epstein-Barr virus.
Antibody responses: Neutrophils zone in to help B cells
Universal expression and dual function of the atypical chemokine receptor D6 on innate-like B cells in mice.
A unifying marker of innate-like B cells is identified, novel B1-cell subsets are described, a dual role for D6 is revealed, and the first evidence of defects in resting D6-deficient mice is provided.
From the editors
historians to plan a " symposium on the History of Technology with papers and sessions that would treat both the history of OMI and broader issues of science, technology,and education from the
Itaconate charges down inflammation
The metabolite itaconate induces electrophilic stress that induces an antioxidant response and regulates secondary TLR transcriptional responses and IL-17-driven pathology.
Immunometabolism: IL-6, the resistance fighter
IL-6 signalling in macrophages limits obesity-associated inflammation and the development of insulin resistance in mice and prevents obesity-related inflammation in mice models ofType 2 diabetes.
T cells: Spotting the troublemakers
  • Yvonne Bordon
  • Biology, Medicine
    Nature Reviews Immunology
  • 24 January 2014