• Publications
  • Influence
Effect of daunorubicin, carminomycin, idarubicin and 4-demethoxydaunorubicinol against human normal myeloid stem cells and human malignant cells in vitro.
The cytotoxic effect of daunorubicin, carminomycin, idarubicin and the major metabolite of idarubicin in man, 4-demethoxydaunorubicinol, was investigated in a human normal progenitor myeloid stemExpand
  • 14
  • 2
Cancer chemotherapy: its role in the treatment strategy of hematologic malignancies and solid tumors.
  • 15
Phase II study of ametantrone in a human tumor cloning assay.
The anticancer activity of ametantrone was investigated in a human tumor cloning assay. Tumor samples were freshly obtained from 105 patients. Cells were exposed for 1 hr to drug concentrations of 1Expand
  • 3
In vitro chemosensitivity testing of flavone acetic acid (LM975; NSC 347512) and its diethylaminoethyl ester derivative (LM985; NSC 293015).
The antitumor effect of flavone acetic acid, LM975, and its diethylaminoethyl ester derivative, LM985, was studied in four human malignant cell lines [WiDr, a colon carcinoma; LICR (LON) HN-3, aExpand
  • 10
Phase I trials of single agents in adult solid tumours: preclinical and clinical aspects.
Considerable progress has been made in the treatment of cancer. However, there is still a need for new drug development. The preclinical antitumour activity of new anticancer agents is evaluated byExpand
  • 5
In vitro chemosensitivity of brain tumors to cisplatin and its analogues, iproplatin and carboplatin
SummaryThe human tumor stem-cell assay was used to investigate the in vitro chemosensitivity of 27 evaluable samples to cisplatin and its analogues, iproplatin and carboplatin, as well as to BCNU,Expand
  • 12
Phase I trial with 4′-deoxydoxorubicin (esorubicin)
Summary4′-Deoxydoxorubicin is a new anthracycline derivative. Experimentally, the drug shows efficacy against doxorubicin-resistant malignancies and, as compared to the parent compound, it hasExpand
  • 10