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This laboratory has demonstrated that a single methamphetamine (METH) injection rapidly and reversibly decreases the activity of the dopamine transporter (DAT), as assessed ex vivo in synaptosomes… (More)
Recent studies demonstrated that vesicular dopamine (DA) uptake can be rapidly altered in synaptic vesicles purified from the striata of stimulant-treated rats. Specifically, a single administration… (More)
Multiple high-dose administrations of the dopamine-releasing agent, methamphetamine, rapidly and persistently decrease vesicular dopamine uptake in purified vesicles prepared from striata of treated… (More)
The vesicular monoamine transporter-2 (VMAT-2) sequesters cytoplasmic monoamines, including dopamine (DA), into synaptic vesicles. It has been suggested that VMAT-2 is resistant to regulation by drug… (More)