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Apelin, a newly identified adipokine up-regulated by insulin and obesity.
The results presented herein demonstrate that apelin is expressed and secreted by both human and mouse adipocytes. Apelin mRNA levels in isolated adipocytes are close to other cell types present inExpand
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The Apelin Receptor Is Coupled to Gi1 or Gi2 Protein and Is Differentially Desensitized by Apelin Fragments*
The apelin receptor is a G protein-coupled receptor to which two ligand fragments, apelin-(65–77) and apelin-(42–77), can bind. To address the physiological significance of the existence of dualExpand
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Expression of a new G protein-coupled receptor X-msr is associated with an endothelial lineage in Xenopus laevis
In order to determine whether G protein-coupled receptors play a role in early embryogenesis, we looked for cDNA fragments amplified between primers located in consensus sequences of transmembraneExpand
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The Adaptor Protein Gab1 Couples the Stimulation of Vascular Endothelial Growth Factor Receptor-2 to the Activation of Phosphoinositide 3-Kinase*
Phosphoinositide 3-kinase (PI3K) mediates essential functions of vascular endothelial growth factor (VEGF), including the stimulation of endothelial cell proliferation and migration. Nevertheless,Expand
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The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors.
While many factors that modulate the morphogenesis and patterning of the embryonic heart have been identified, relatively little is known about the molecular events that regulate the differentiationExpand
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Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein.
We report here that apelin (65-77) induces activation of extracellular-regulated kinases (ERKs) in Chinese hamster ovary (CHO) cells expressing the msr/apj receptor. This concentration-dependentExpand
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Apelin (65‐77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells
We report here that apelin (65‐77) activates p70 S6 kinase (p70S6K), not only in CHO cells that have been stably transfected with the apelin receptor, but also in umbilical endothelial cells (HUVEC),Expand
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Apelin is a potent activator of tumour neoangiogenesis
Our laboratory has previously shown that apelin is mitogenic for endothelial cells. We have postulated that apelin represents an angiogenic factor secreted by tumour cells in order to promote theExpand
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Evidence for multiple “kappa” binding sites by use of opioid peptides in the guinea-pig lumbo-sacral spinal cord
Binding properties of [3H]-etorphine and [3H]-ethylketocyclazocine have been studied in the lumbo-sacral spinal cord of guinea-pig which does not contain mu or delta binding sites. [3H]-etorphineExpand
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Tumour co-expression of apelin and its receptor is the basis of an autocrine loop involved in the growth of colon adenocarcinomas.
Using a cancer profiling array, our laboratory has shown that apelin gene is up-regulated in half of colon adenocarcinomas. We have therefore postulated that apelin signalling might play a prominentExpand
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