Learn More
— Grasping has been well studied in the robotics and human subjects literature, and numerous taxonomies have been developed to capture the range of grasps employed in work settings or everyday life. But how completely do these taxonomies capture grasping actions that we see every day? We asked two subjects to monitor every action that they performed with(More)
Antibodies produced by an individual without a known history of sensitization to the relevant antigen are called "natural" antibodies. Some natural antibodies, called xenoreactive antibodies, react with the cells of foreign species. Most xenoreactive antibodies in humans and higher primates bind to a nonreducing terminal galactose expressed by pigs and(More)
Natural anti-carbohydrate antibodies in humans play a key role in natural immunity and in recognition of allogeneic and xenogeneic antigens. Presumably, natural anti-carbohydrate antibodies in mice have similar functions; but these antibodies have not been extensively characterized. An assay was developed and used to screen for anti-carbohydrate IgM in the(More)
Mice lacking the alpha-galactosyl transferase gene (GalT(-/-) mice) have been used extensively as a model for xenotransplantation. Unlike wild type (WT) mice, GalT(-/-) mice do not produce Gal alpha 1-3Gal and are known to produce natural IgM specific for Gal alpha 1-3Gal, as do humans and higher primates. In addition to natural anti-Gal alpha 1-3Gal IgM in(More)
BACKGROUND Natural antibodies directed against cell surface carbohydrates are thought to be vital to host defense and to initiate the rejection of xenografts and ABO-incompatible allografts. The biophysical properties underlying the association and dissociation of these antibodies from cell surfaces is incompletely understood. We investigated those(More)
Grasping has been well studied in the robotics and human subjects literature, and numerous taxonomies have been developed to capture the range of grasps employed in work settings or everyday life. But how completely do these taxonomies capture grasping actions that we see every day? In a study to classify all actions during a typical day, we found that(More)
  • 1