Yuzu Kubota

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BACKGROUND AND AIMS Cathelicidin (LL-37 in human and mCRAMP in mice) represents a family of endogenous antimicrobial peptides with anti-inflammatory effects. LL-37 also suppresses collagen synthesis, an important fibrotic response, in dermal fibroblasts. Here we determined whether exogenous cathelicidin administration modulates intestinal fibrosis in two(More)
BACKGROUND Cathelicidin (LL-37 in humans and mCRAMP in mice) represents a family of endogenous antimicrobial and anti-inflammatory peptides. Cancer-associated fibroblasts can promote the proliferation of colon cancer cells and growth of colon cancer tumors. METHODS We examined the role of cathelicidin in the development of colon cancer, using subcutaneous(More)
BACKGROUND A single dose of allogeneic cardiosphere-derived cells (CDCs) improves cardiac function and reduces scarring, and increases viable myocardium in the infarcted rat and pig heart without eliciting a detrimental immune response. Clinical trials using single doses of allogeneic human CDCs are underway. It is unknown whether repeat dosing confers(More)
Center for Inflammatory Bowel Diseases; Division of Digestive Diseases, David Geffen School of Medicine, The University of California Los Angeles, Los Angeles, CA Corresponding author: Hon Wai Koon, Ph.D. Center for Inflammatory Bowel Diseases, MRL 1519, 675 Charles E. Young Drive South, The University of California Los Angeles, Los Angeles, CA 90095,(More)
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