Yuzhong Zhang

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BACKGROUND Severe fever with thrombocytopenia syndrome virus (SFTSV), which can cause hemorrhagic fever-like illness, is a newly discovered bunyavirus in China. The pathogenesis of SFTSV infection is poorly understood. However, it has been suggested that immune mechanisms, including cytokines and chemokines, play an important role in disease pathogenesis.(More)
A series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (4a)(More)
In this paper, we address the scheduling problem with rejection and non-identical job arrivals, in which we may choose not to process certain jobs and each rejected job incurs a penalty. Our goal is to minimize the sum of the total penalties of the rejected jobs and the maximum completion time of the processed ones. For the off-line variant, we prove its(More)
A series of novel ligustrazine-oleanolic acid (TOA) derivatives were designed, and synthesized by conjugating amino acids to the 3-hydroxy group of TOA by ester bonds. Their cytotoxicity was evaluated on four cancer cell lines (HepG2, HT-29, Hela and BGC-823) by standard MTT assays. The ClogP values were calculated by means of computer simulation, and logP(More)
a r t i c l e i n f o a b s t r a c t Keywords: Analysis of algorithms Parallel-batch scheduling Deteriorating job NP-hard Fully polynomial time approximation scheme (FPTAS) We consider the bounded parallel-batch scheduling problem in which the processing time of a job is a simple linear function of its starting time. The objective is to minimize the(More)