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We identified an NH2-terminally truncated HER-2/neu product of M(r) 95,000 with in vitro kinase activity by Western blotting and immunoprecipitations using domain-specific antibodies. p95 levels correlated with the extracellular domain (ECD) shed from different cells under varied conditions. Both ECD and p95 were at approximately 20-fold lower levels in(More)
This paper presents the practices of a research aiming at the design of a context-aware recommendation system that promotes the adoption of a healthy and active lifestyle. A Smartphone application that provides personalized and contextualized advice on physical activities was developed. The goal of our endeavor is to find out whether this recommendation(More)
This paper presents the design, implementation and evaluation of a context-aware recommendation system that promotes the adoption of a healthy and active lifestyle. A Smartphone application that provides personalized and contextualized advice based on geo information, weather, user location and agenda was developed and evaluated by a user study. The results(More)
Recurrent laryngeal papillomas are tumors believed to be induced by human papillomaviruses. Severity of this disease varies due to the unpredictability of clinical remissions and recurrences. However, the severity of the disease does not affect the classification of these tumors as benign, and the rate of spontaneous conversion of recurrent laryngeal(More)
Ten primary squamous cell carcinomas (SCC) of the head and neck were evaluated cytogenetically after 10-14 days of in vitro culture. Addition of 3% L-glutamine was essential for consistent epithelial growth of these carcinomas. Outgrowth of cells from tissue explants contained a mixture of chromosomally normal and abnormal cells; the abnormal cells had(More)
Enhanced levels of disulfide-linked dimers of the neu oncogene product have been suggested to be associated with the transformed state [Weiner DB, Liu J, Cohen JA, Williams WV, Greene MI: Nature 338:230-231, (1989)]. We, therefore, investigated the properties of the dimeric forms of p185HER-2/neu from the human breast carcinoma cell line, SK-BR-3. We found(More)
OBJECTIVE Retrospective audit of IVIG Request Forms in four Ontario tertiary care centres: to determine the case mix of new IVIG requests, to authenticate information provided, and to determine documentation of clinical efficacy. AIMS To understand contributors to increases in IVIG utilisation and to determine whether IVIG is being used and monitored(More)
We identified an MI ,-U>rmm;ill> truncated HER-2/neu product of M, 95,000 with in vitro kinase activity by Western blotting and immunoprecipitations using domain-specific antibodies. p95 levels correlated with the extracellular domain (ECD) shed from different cells under varied con ditions. Both ECD and p95 were at -20-fold lower levels in SKOV3 ovarian(More)
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