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Metabolomics study on the anti-depression effect of xiaoyaosan on rat model of chronic unpredictable mild stress.
Antidepressant-like effects of the fractions of Xiaoyaosan on rat model of chronic unpredictable mild stress.
Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry.
Uncovering the anticancer mechanism of Compound Kushen Injection against HCC by integrating quantitative analysis, network analysis and experimental validation
- Li Gao, Ke-xin Wang, Yuzhi Zhou, Jian-song Fang, X. Qin, G. Du
- Biology, ChemistryScientific Reports
- 12 January 2018
The results indicated that CKI exerted anti-HCC effects via the key targets MMP2, MYC, CASP3, and REG1A and the key pathways of glycometabolism and amino acid metabolism.
Dynamic analysis of the endogenous metabolites in depressed patients treated with TCM formula Xiaoyaosan using urinary (1)H NMR-based metabolomics.
Study of plasma metabolic profiling and biomarkers of chronic unpredictable mild stress rats based on gas chromatography/mass spectrometry.
- Zhen-Yu Li, Xing-Yu Zheng, X. Qin
- BiologyRapid communications in mass spectrometry : RCM
- 30 December 2010
The study suggested that the metabolomics approach could be used as a potential powerful tool to investigate the biochemical change in certain physiopathological conditions, such as depression, as an early diagnostic means.
A GC-MS urinary quantitative metabolomics analysis in depressed patients treated with TCM formula of Xiaoyaosan.
Research on the Pathological Mechanism and Drug Treatment Mechanism of Depression
- Guo-jiang Peng, Junsheng Tian, Xiaoxia Gao, Yuzhi Zhou, X. Qin
- Psychology, MedicineCurrent neuropharmacology
- 30 June 2015
The most recent hypotheses and metabolomics based research including hereditary, neurotransmitter systems, brain derived neurotrophic factor (BDNF), hyperactivity of the hypothalamic pituitary adrenal axis and inflammatory as well as metabolomics were summarized.
Ginger extract extends the lifespan of Drosophila melanogaster through antioxidation and ameliorating metabolic dysfunction
Protective effect of isoliquiritin against corticosterone-induced neurotoxicity in PC12 cells.
In conclusion, isoliquiritin has a cytoprotective effect on corticosterone-induced neurotoxicity in PC12 cells, which may be related to its antioxidant action, inhibition of [Ca2+]i overload and inhibition of the mitochondrial apoptotic pathway.