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The Moderate Resolution Imaging Spectroradiometer (MODIS) on board the NASA Terra satellite has been collecting global data since March 2000 and on the Aqua satellite since June 2002. In this paper we compare cirrus cloud properties derived from ground-based remote sensing data with similar cloud properties derived from MODIS data on Terra. In order to(More)
The progranulin (PGRN) is known to protect regulatory T cells (Tregs) from a negative regulation by TNF-α, and its levels are elevated in various kinds of autoimmune diseases. Whether PGRN directly regulates the conversion of CD4+CD25-T cells into Foxp3-expressing regulatory T cells (iTreg), and whether PGRN affects the immunosuppressive function of Tregs,(More)
Glycogen synthase kinase-3 (GSK-3) plays a critical role in neuronal apoptosis. The two mammalian isoforms of the kinase, GSK-3α and GSK-3β, are inhibited by phosphorylation at Ser-21 and Ser-9, respectively. Depolarization, which is vital for neuronal survival, causes both an increase in Ser-21/9 phosphorylation and an inhibition of GSK-3α/β. However, the(More)
Physical inactivity is an important contributor to the development of numerous chronic conditions and alone is an independent risk factor for diabetes, cardiovascular disease, and depression and yet, most Americans consistently fail to achieve the recommended amount of physical activity. As part of Project HealthDesign, we designed and prototyped a personal(More)
[1] The mesoscale patterns of cloud/precipitation radar reflectivity from early CloudSat data are used to identify distinct tropical cloud regimes via a cluster analysis. Five basic cloud regimes are identified, and the geographical distribution of their occurrence frequency is quantified. Although the contemporary MODIS observations show some limitations(More)
Algorithms are developed to convert data streams from multiple airborne and spaceborne remote sensors into layer-averaged cirrus bulk microphysical properties. Radiometers such as the Moderate-Resolution Imaging Spectroradiometer (MODIS) observe narrowband spectral radiances, and active remote sensors such as the lidar on the Cloud–Aerosol Lidar and(More)
The correspondence between short-and long-timescale systematic errors in the Community Atmospheric Model, version 4 (CAM4) and version 5 (CAM5), is systematically examined. The analysis is based on the annual-mean data constructed from long-term ''free running'' simulations and short-range hindcasts. The hindcasts are initialized every day with the ECMWF(More)
This study was aimed to determine the role and regulation of progranulin (PGRN) in the pathogenesis of inflammatory bowel diseases (IBD). Dextran sulfate sodium (DSS)-, picrylsulfonic acid (TNBS)-induced, bone marrow chimera and CD4+CD45Rb(hi) T cell transfer colitis model were established and analyzed in wild-type and several genetically-modified mice,(More)
During the intracellular life of Salmonella enterica, a unique membrane-bound compartment termed Salmonella-containing vacuole, or SCV, is formed. By means of translocated effector proteins, intracellular Salmonella also induce the formation of extensive, highly dynamic membrane tubules termed Salmonella-induced filaments or SIF. Here we report the first(More)
[Purpose] The purpose of this this study was to examine the immediate effects of intervention of proprioceptive neuromuscular facilitation (PNF), neuromuscular joint facilitation (NJF) and NJF+pelvic floor muscle (PFM) exercise. [Subjects] Thirteen young people (5 males, 8 females) who had chronic low back pain on one side for more than 6 months. [Methods](More)